Critical Role of Antimicrobial Peptide Cathelicidin for Controlling Helicobacter pylori Survival and Infection

The Journal of Immunology : Official Journal of the American Association of Immunologists
Lin ZhangChi H Cho

Abstract

The antimicrobial peptide cathelicidin is critical for protection against different kinds of microbial infection. This study sought to elucidate the protective action of cathelicidin against Helicobacter pylori infection and its associated gastritis. Exogenous cathelicidin was found to inhibit H. pylori growth, destroy the bacteria biofilm, and induce morphological alterations in H. pylori membrane. Additionally, knockdown of endogenous cathelicidin in human gastric epithelial HFE-145 cells markedly increased the intracellular survival of H. pylori. Consistently, cathelicidin knockout mice exhibited stronger H. pylori colonization, higher expression of proinflammatory cytokines IL-6, IL-1β, and ICAM1, and lower expression of the anti-inflammatory cytokine IL-10 in the gastric mucosa upon H. pylori infection. In wild-type mice, H. pylori infection also stimulated gastric epithelium-derived cathelicidin production. Importantly, pretreatment with bioengineered Lactococcus lactis that actively secretes cathelicidin significantly increased mucosal cathelicidin levels and reduced H. pylori infection and the associated inflammation. Moreover, cathelicidin strengthened the barrier function of gastric mucosa by stimulating mucus synthes...Continue Reading

References

Jan 1, 1997·Glycoconjugate Journal·F CarvalhoM Sobrinho-Simões
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·R BalsJ M Wilson
Jun 26, 1999·Helicobacter·G H KoK H Rhee
Jun 1, 2002·Applied and Environmental Microbiology·D DjordjevicL A McLandsborough
Dec 19, 2003·Nature Reviews. Cancer·Michael A Hollingsworth, Benjamin J Swanson
Mar 26, 2004·Nature Reviews. Microbiology·Luanne Hall-StoodleyPaul Stoodley
Jun 29, 2005·The Journal of Investigative Dermatology·Belén López-GarcíaRichard L Gallo
May 23, 2006·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Michael A CarronJames M Coticchia
May 25, 2006·The Journal of Biological Chemistry·Igor ZelezetskyAlessandro Tossi
Jun 14, 2006·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·James M CoticchiaMichael A Carron
Oct 28, 2006·The Lancet Infectious Diseases·Monique M GerritsJohannes G Kusters
May 17, 2007·Nature Reviews. Microbiology·Sebastian Suerbaum, Christine Josenhans
Aug 7, 2007·Nature Medicine·Kenshi YamasakiRichard L Gallo
Jul 2, 2008·Antimicrobial Agents and Chemotherapy·Guangshun WangRobert W Buckheit
Sep 15, 2009·Cell Host & Microbe·Jae-Min YukEun-Kyeong Jo
May 1, 2010·The Journal of Biological Chemistry·Wei GuangErik P Lillehoj
Jul 14, 2010·Journal of Gastroenterology and Hepatology·Hideo YonezawaShigeru Kamiya
Aug 6, 2010·International Journal of Antimicrobial Agents·Sakawarat KanthawongSuwimol Taweechaisupapong
Aug 31, 2010·Applied and Environmental Microbiology·Matjaz RavnikarAles Berlec
Dec 18, 2010·Nature Reviews. Microbiology·Julian G HurdleRichard E Lee
Mar 26, 2011·Helicobacter·Feng-Ling YangBow Ho
May 5, 2011·Peptides·Jack Ho WongDavid Chi Cheong Wan
Oct 19, 2011·International Journal of Antimicrobial Agents·Sakawrat KanthawongSuwimol Taweechaisupapong
Feb 7, 2012·Cancer Letters·Shikha TarangSurinder K Batra
Mar 13, 2012·Helicobacter·Luisa F Jiménez-SotoRainer Haas
Apr 18, 2012·Journal of Gastroenterology and Hepatology·Clover Ching Man WongChi Hin Cho
Jun 2, 2012·Alimentary Pharmacology & Therapeutics·G CammarotaB Posteraro
Jul 26, 2012·Gastroenterology Research and Practice·Wenming WuGang Sun

❮ Previous
Next ❯

Citations

Jun 18, 2016·Lipids in Health and Disease·Guozhong LouYu Xia
Aug 5, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tânia Silva, Maria Salomé Gomes
Nov 16, 2018·Helicobacter·Alireza NeshaniKiarash Ghazvini
Mar 1, 2018·Scientific Reports·Nagendran TharmalingamEleftherios Mylonakis
Jan 19, 2019·Applied Microbiology and Biotechnology·Tina Vida Plavec, Aleš Berlec
Feb 12, 2020·Critical Care : the Official Journal of the Critical Care Forum·Jeffery HoWilliam K K Wu
Aug 18, 2016·Helicobacter·Steffen BackertMichael Naumann
Mar 7, 2021·Cellular and Molecular Gastroenterology and Hepatology·Fang-Yuan MaoYuan Zhuang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biofilm & Infectious Disease

Biofilm formation is a key virulence factor for a wide range of microorganisms that cause chronic infections.Here is the latest research on biofilm and infectious diseases.

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Biofilms

Biofilms are adherent bacterial communities embedded in a polymer matrix and can cause persistent human infections that are highly resistant to antibiotics. Discover the latest research on Biofilms here.