Critical role of c-Kit in beta cell function: increased insulin secretion and protection against diabetes in a mouse model.

Diabetologia
Z C FengRennian Wang

Abstract

The receptor tyrosine kinase, c-Kit, and its ligand, stem cell factor, control a variety of cellular processes, including pancreatic beta cell survival and differentiation as revealed in c-Kit ( Wv ) mice, which have a point mutation in the c-Kit allele leading to loss of kinase activity and develop diabetes. The present study further investigated the intrinsic role of c-Kit in beta cells, especially the underlying mechanisms that influence beta cell function. We generated a novel transgenic mouse model with c-KIT overexpression specifically in beta cells (c-KitβTg) to further examine the physiological and functional roles of c-Kit in beta cells. Isolated islets from these mice were used to investigate the underlying molecular pathway of c-Kit in beta cells. We also characterised the ability of c-Kit to protect animals from high-fat-diet-induced diabetes, as well as to rescue c-Kit ( Wv ) mice from early onset of diabetes. c-KitβTg mice exhibited improved beta cell function, with significantly improved insulin secretion, and increased beta cell mass and prolifera...Continue Reading

References

Dec 3, 1999·The International Journal of Biochemistry & Cell Biology·L K Ashman
Dec 3, 1999·The International Journal of Biochemistry & Cell Biology·D Linnekin
Nov 30, 2000·Upsala Journal of Medical Sciences·M WelshC Oberg-Welsh
Feb 7, 2001·Proceedings of the National Academy of Sciences of the United States of America·S DuttaM Montminy
Jan 10, 2002·The Journal of Biological Chemistry·Marcela BrissovaAlvin C Powers
Jul 13, 2002·The Journal of Pathology·Susan Bonner-Weir, Arun Sharma
Sep 10, 2002·American Journal of Physiology. Endocrinology and Metabolism·Bo Ahrén, Giovanni Pacini
Mar 26, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Nina Kaur YashpalRennian Wang
Dec 17, 2004·Pediatric Diabetes·Jeremy J Heit, Seung K Kim
Jan 22, 2005·Virchows Archiv : an International Journal of Pathology·Katharina PetersRennian Wang
Apr 16, 2005·Molecular and Cellular Biology·Jake A KushnerMorris F White
Jun 18, 2005·Molecular & Cellular Proteomics : MCP·Linghua QiuJohn J Kopchick
Oct 11, 2005·The International Journal of Biochemistry & Cell Biology·Jinming LiRennian Wang
Mar 22, 2006·Pediatric Research·Juris J MeierPeter C Butler
Jan 20, 2007·Virchows Archiv : an International Journal of Pathology·Katharina TiemannGünter Klöppel
May 24, 2007·American Journal of Physiology. Endocrinology and Metabolism·Jinming LiRennian Wang
Jul 7, 2009·Developmental Biology·Wataru NishimuraArun Sharma
Dec 8, 2009·Endocrinology·Suhuan Liu, Franck Mauvais-Jarvis
Dec 31, 2010·Diabetologia·C Aguayo-MazzucatoS Bonner-Weir
Jan 18, 2012·Laboratory Investigation; a Journal of Technical Methods and Pathology·Zhi-Chao FengRennian Wang

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Citations

Apr 4, 2013·Investigative Ophthalmology & Visual Science·Han PengRobert M Lavker
Aug 2, 2013·International Journal of Biological Sciences·Yan-Ling WuWen Zhang
Aug 26, 2014·Pharmacological Reports : PR·Edyta SzałekEdmund Grześkowiak
Jun 12, 2014·Diabetes·Dario A GutierrezHans-Reimer Rodewald
Oct 24, 2015·Trends in Endocrinology and Metabolism : TEM·Athanasios FountasAgathocles Tsatsoulis
Feb 12, 2017·International Journal of Biological Macromolecules·Jun LvPeiyuan Xia
Jun 6, 2012·Nature Reviews. Endocrinology·Joana Osório
May 26, 2018·PloS One·Mariko TagaJacques Hugon
Jan 10, 2021·Gastroenterology·Rajan SinghSeungil Ro
Feb 2, 2021·Journal of Diabetes and Metabolic Disorders·D HimanshuMohd Wamique
Dec 18, 2018·Pharmacology & Therapeutics·Asuncion Martinez-AntonPascal Chanez

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