Critical role of donor tissue expression of programmed death ligand-1 in regulating cardiac allograft rejection and vasculopathy.

Circulation
Jun YangA Chandraker

Abstract

Allograft vasculopathy is a major limiting factor in the long-term success of cardiac transplantation. T cells play a critical role in initiation of cardiac allograft rejection and allograft vasculopathy. The negative T-cell costimulatory pathway PD-1:PDL1/PDL2 (programmed death-1:programmed death ligand-1/2) plays an important role in regulating alloimmune responses. We investigated the role of recipient versus donor PD-1 ligands in the pathogenesis of allograft rejection with emphasis on the role of tissue expression in regulating this alloimmune response in vivo. We used established major histocompatibility complex class II- and class I-mismatched models of vascularized cardiac allograft rejection, blocking anti-PDL1 and anti-PDL2 antibodies, and PDL1- and PDL2-deficient mice (as donors or recipients) to study the role of the PD-1:PDL1/PDL2 pathway in chronic rejection. We also used PDL1-deficient and wild-type mice and bone marrow transplantation to generate chimeric animals that express PDL1 exclusively on either hematopoietic or parenchymal cells. PDL1 but not PDL2 blockade significantly accelerated cardiac allograft rejection in the bm12-into-B6 and B6-into-bm12 models. Although wild-type cardiac allografts survived long...Continue Reading

References

Jun 17, 1998·The Journal of Clinical Investigation·A ChandrakerM H Sayegh
Feb 27, 2001·Nature Immunology·Y LatchmanG J Freeman
Sep 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Melissa M Mazanet, Christopher C W Hughes
Nov 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tomohide YamazakiHideo Yagita
Nov 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Engin OzkaynakWayne W Hancock
Mar 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xueli YuanMohamed H Sayegh
Apr 16, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Mohamed H SayeghLaurence A Turka
Jul 9, 2003·The Journal of Experimental Medicine·Mohammed Javeed I AnsariMohamed H Sayegh
Jul 9, 2003·The Journal of Experimental Medicine·Alan D SalamaSamia J Khoury
Sep 30, 2003·European Journal of Immunology·Spencer C LiangArlene H Sharpe
Oct 28, 2003·European Journal of Immunology·Nancy RodigGordon J Freeman
Nov 18, 2003·Immunological Reviews·David M Rothstein, Mohamed H Sayegh
Mar 23, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Holger SchmidMatthias Kretzler
Sep 9, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Roland SchoopRudolf P Wüthrich
Sep 18, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Noritaka KogaMitsuaki Isobe
Dec 24, 2004·The New England Journal of Medicine·Mohamed H Sayegh, Charles B Carpenter
Mar 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sigrid E SandnerMohamed H Sayegh
Mar 18, 2005·Annual Review of Immunology·Rebecca J GreenwaldArlene H Sharpe
May 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Toshiro ItoNader Najafian
Jul 20, 2005·The Journal of Experimental Medicine·Indira GuleriaMohamed H Sayegh
Dec 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Antje HabichtMohamed H Sayegh
Apr 12, 2006·The Journal of Experimental Medicine·Mary E KeirArlene H Sharpe
Aug 4, 2006·The Journal of Clinical Investigation·Mohammed Javeed Ansari, Mohamed H Sayegh
Apr 14, 2007·Circulation Research·Richard N Mitchell, Peter Libby
Oct 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katsunori TanakaNader Najafian

❮ Previous
Next ❯

Citations

Jul 13, 2013·Bioorganic & Medicinal Chemistry Letters·Darin J GustinZhulun Wang
Oct 13, 2011·Molecular Therapy : the Journal of the American Society of Gene Therapy·Soosan GhazizadehWeibing Zhang
Dec 3, 2008·The Journal of Experimental Medicine·Xueli YuanM Javeed Ansari
Jun 14, 2008·Biology of Reproduction·Elizabeth S TaglauerMargaret G Petroff
Sep 27, 2012·Dermatitis : Contact, Atopic, Occupational, Drug·Shinjita DasPonciano D Cruz
Feb 28, 2009·Journal of Cardiovascular Pharmacology·Joel S Karliner
Dec 22, 2011·Current Opinion in Organ Transplantation·Anna Valujskikh, Xian C Li
Jun 22, 2012·Journal of Transplantation·Marcos V SilvaRosana R M Corrêa
Oct 6, 2009·Future Lipidology·Megan M PriceSarah Spiegel
Apr 16, 2010·Kidney International·Astrid StarkeYing Waeckerle-Men
Dec 6, 2011·Seminars in Immunology·Jean KwunStuart J Knechtle
Mar 26, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Yan ChenPaul Kwong Hang Tam
Nov 26, 2009·Veterinary Immunology and Immunopathology·A Folkl, D Bienzle
Apr 17, 2009·Journal of Reproductive Immunology·Elizabeth S TaglauerMargaret G Petroff
May 12, 2009·Immunological Reviews·Xian C LiMohamed H Sayegh
Jul 30, 2008·Transplant International : Official Journal of the European Society for Organ Transplantation·Maria-Luisa del RioJose-Ignacio Rodriguez-Barbosa
Jan 4, 2012·Transplant International : Official Journal of the European Society for Organ Transplantation·Christian DeneckeStefan G Tullius
Mar 16, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·L V RiellaN Najafian
Mar 26, 2013·European Journal of Immunology·Leonardo V RiellaAnil Chandraker
Jul 5, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C N MageeN Najafian
Aug 21, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·L V RiellaA Chandraker
Apr 1, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K YamauraN Najafian
Oct 23, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J YangA Chandraker
Jan 15, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A M K KaulW M Baldwin
Feb 6, 2015·Journal of Cardiovascular Translational Research·Patricia van den HoogenRoel A de Weger
Jan 8, 2015·Current Opinion in Organ Transplantation·Edward B ThorpM Javeed Ansari
May 19, 2016·Immunity·Mandy L Ford
Aug 19, 2015·PLoS Neglected Tropical Diseases·Xiaojun ChenChuan Su
Jun 9, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J S YoungA S Chong
Aug 8, 2008·Current Opinion in Organ Transplantation·Olaf BoenischNader Najafian
Jul 26, 2018·Transplantation·Anna Valujskikh
Aug 24, 2018·Xenotransplantation·Mo ChenYong-Guang Yang
Apr 8, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lalit BatraEsma S Yolcu
Jun 24, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jun YangMohamed H Sayegh
May 8, 2018·Scientific Reports·Shuzo TeruyaKeishi Fujio
Sep 8, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Magali Noval RivasMichel Y Braun
Aug 1, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hideaki FujiwaraMitsune Tanimoto

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Basal Ganglia Cerebrovascular Disease

Basal ganglia cerebrovascular disease is a condition where the blood vessels in the basal ganglia are damaged or malfunction. Discover the latest research on basal ganglia cerebrovascular disease here.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.