Critical Role of Intracellular RyR1 Calcium Release Channels in Skeletal Muscle Function and Disease

Frontiers in Physiology
Erick O Hernández-OchoaMartin F Schneider

Abstract

The skeletal muscle Ca(2+) release channel, also known as ryanodine receptor type 1 (RyR1), is the largest ion channel protein known and is crucial for effective skeletal muscle contractile activation. RyR1 function is controlled by Cav1.1, a voltage gated Ca(2+) channel that works mainly as a voltage sensor for RyR1 activity during skeletal muscle contraction and is also fine-tuned by Ca(2+), several intracellular compounds (e.g., ATP), and modulatory proteins (e.g., calmodulin). Dominant and recessive mutations in RyR1, as well as acquired channel alterations, are the underlying cause of various skeletal muscle diseases. The aim of this mini review is to summarize several current aspects of RyR1 function, structure, regulation, and to describe the most common diseases caused by hereditary or acquired RyR1 malfunction.

References

Apr 25, 1977·Pflügers Archiv : European journal of physiology·P R Stanfield
Oct 1, 1978·The Journal of Physiology·J A Sanchez, E Stefani
Jun 1, 1977·The Journal of Physiology·R H Adrian, M W Marshall
Dec 20, 1992·Journal of Molecular Biology·R ChattopadhyayaF A Quiocho
Nov 1, 1988·The Journal of Physiology·M F Schneider, B J Simon
Jun 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·D H MacLennan, P T Wong
Jul 1, 1973·Physiological Reviews·J I Hubbard
Nov 1, 1973·The Journal of Physiology·R H Adrian, L D Peachey
Sep 1, 1969·The Journal of Physiology·R H AdrianL D Peachey
Jul 1, 1970·The Journal of Physiology·R H AdrianA L Hodgkin
Apr 1, 1983·Journal of Muscle Research and Cell Motility·C Franzini-Armstrong, G Nunzi
Aug 24, 1995·Biochemical and Biophysical Research Communications·R BurattiF Zorzato
Jun 1, 1995·Journal of Muscle Research and Cell Motility·C Franzini-Armstrong, J W Kish
May 8, 1995·Biochimica Et Biophysica Acta·W MelzerH C Lüttgau
Jan 1, 1994·Annual Review of Physiology·C Franzini-Armstrong, A O Jorgensen
Feb 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·J NakaiK G Beam
Nov 1, 1995·Neuromuscular Disorders : NMD·A McArdleM J Jackson
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·R G GreggP A Powers
Jul 1, 1997·Physiological Reviews·C Franzini-Armstrong, F Protasi
Jun 5, 1998·The Journal of Biological Chemistry·J NakaiK G Beam

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Citations

Nov 5, 2016·Pflügers Archiv : European journal of physiology·Birgitta C BurckhardtGerhard Burckhardt
Dec 17, 2017·The Journal of General Physiology·Alberto ZulloWerner Melzer
Sep 25, 2019·Journal of Cellular Physiology·Daniela CalziaPaolo Degan
May 11, 2017·International Journal of Molecular Sciences·Florence N ReddishJenny J Yang
May 28, 2020·International Journal of Molecular Sciences·George Konstantinos PapadimasConstantinos Papadopoulos
Feb 18, 2020·Biochemical Society Transactions·Rossella VendittiMaria Antonietta De Matteis
Nov 11, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ayaka TabuchiYutaka Kano

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Methods Mentioned

BETA
enzymatic dissociation
biopsies

Software Mentioned

UCSF Chimera

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