Critical role of mitosis in spontaneous late-onset Alzheimer's disease; from a Shugoshin 1 cohesinopathy mouse model

Cell Cycle
Chinthalapally V RaoHiroshi Y Yamada

Abstract

From early-onset Alzheimer's disease (EOAD) studies, the amyloid-beta hypothesis emerged as the foremost theory of the pathological causes of AD. However, how amyloid-beta accumulation is triggered and progresses toward senile plaques in spontaneous late-onset Alzheimer's disease (LOAD) in humans remains unanswered. Various LOAD facilitators have been proposed, and LOAD is currently considered a complex disease with multiple causes. Mice do not normally develop LOAD. Possibly due to the multiple causes, proposed LOAD facilitators have not been able to replicate spontaneous LOAD in mice, representing a disease modeling issue. Recently, we reported spontaneous late-onset development of amyloid-beta accumulation in brains of Shugoshin 1 (Sgo1) haploinsufficient mice, a cohesinopathy-mediated chromosome instability model. The result for the first time expands disease relevance of mitosis studies to a major disease other than cancers. Reverse-engineering of the model would shed light on the process of late-onset amyloid-beta accumulation in the brain and spontaneous LOAD development, and contribute to development of interventions for LOAD. This review will discuss the Sgo1 model, our current "three-hit hypothesis" regarding LOAD dev...Continue Reading

References

Dec 1, 1996·Journal of Neurochemistry·C M Kondratick, D D Vandré
Sep 6, 2002·Journal of Alzheimer's Disease : JAD·Andrei TomashevskiInez Vincent
Nov 9, 2002·Journal of Neurochemistry·Patrice DelobelLuc Buée
Mar 25, 2004·Lancet Neurology·Xiongwei ZhuMark A Smith
Jun 23, 2004·Nature Genetics·Darren J BakerJan M van Deursen
Mar 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·Chinthalapally V RaoWei Dai
Jun 7, 2005·Mechanisms of Ageing and Development·Kate M WebberMark A Smith
Dec 5, 2006·Biochimica Et Biophysica Acta·Xiongwei ZhuMark A Smith
Dec 13, 2006·Biochimica Et Biophysica Acta·Yan Yang, Karl Herrup
Dec 27, 2006·Cancer Cell·Beth A A WeaverDon W Cleveland
Mar 12, 2008·Developmental Cell·William Y Tsang, Brian David Dynlacht
Aug 5, 2008·Trends in Genetics : TIG·Robin M RickeJan M van Deursen
Aug 19, 2008·Biochimica Et Biophysica Acta·Floris FoijerPeter K Sorger
Oct 8, 2008·Trends in Pharmacological Sciences·Domenico Praticò
Jun 17, 2009·The Journal of Cell Biology·Beth A A Weaver, Don W Cleveland
Jul 22, 2009·Progress in Neurobiology·Wei WangDeding Tao
Jan 23, 2010·Nature Reviews. Cancer·Juan-Manuel SchvartzmanRobert Benezra
Sep 2, 2010·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Lada ZivkovićVladan Bajić
Dec 15, 2010·Frontiers in Neuroscience·Jun Ming Wang, Chenyou Sun
Jul 12, 2011·Nature Cell Biology·Laura SchöckelOlaf Stemmann
Dec 7, 2011·Brain Research Bulletin·Alicia M Hall, Erik D Roberson
Feb 1, 2012·Current Pharmaceutical Design·Masashi KitazawaFrank M Laferla
Mar 3, 2012·Medical Hypotheses·Allen J Orehek

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Citations

Sep 14, 2019·Cell Cycle·Jessica PichéGregor Andelfinger
Dec 4, 2019·Frontiers in Genetics·Huntington PotterAntoneta Granic

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Methods Mentioned

BETA
transgenic

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