Critical role of surgery in patients with gastroesophageal carcinoma with a poor prognosis after chemoradiation as defined by positron emission tomography

Cancer
Srikrishna V PatnanaJaffer A Ajani

Abstract

The prognosis of patients with localized gastroesophageal carcinoma (LGC) can be defined after chemoradiation by the standardized uptake value (SUV) of positron emission tomography (PET). High SUV (HSUV) after chemoradiation portends a poor prognosis. The authors retrospectively examined the role of surgery in patients with HSUV after chemoradiation. The authors analyzed the postchemoradiation PET scans of 204 LGC patients. One hundred twenty-nine patients had HSUV. Two postchemoradiation variables were evaluated: SUV and surgery and their association with overall survival (OS) and event-free survival (EFS). The log-rank test, multivariate Cox proportional hazards model, and Kaplan-Meier survival plots were used to assess the association between OS or EFS and the dichotomized SUV (using the median SUV as the cutoff) and surgery. The median SUV was 4.6. The OS of the 52 patients who had an SUV above the median and did not undergo surgery (HSUV-NS) (median OS, 1.22 years; 95% confidence interval [95% CI], 1.02-2.16 years) was much shorter than that of the 77 patients with an SUV above the median who underwent surgery (HSUV-S) (median OS, 2.7 years; 95% CI, 2.43 years to not reached [P<.0001]). Similarly, the EFS for patients with...Continue Reading

References

Aug 15, 1996·The New England Journal of Medicine·T N WalshT P Hennessy
Nov 21, 1998·The British Journal of Surgery·J R Siewert, H J Stein
Sep 14, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P FlamenL Mortelmans
Feb 24, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S G UrbaM Strawderman
Jun 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W A WeberU Fink
May 29, 2003·The Journal of Thoracic and Cardiovascular Surgery·Thomas W RiceJohn R Goldblum
Jun 28, 2003·International Journal of Radiation Oncology, Biology, Physics·Mohan SuntharalingamUNKNOWN 1996-1999 Patterns of Care Study
Mar 3, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hinrich A WiederWolfgang A Weber
Apr 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mohan SuntharalingamJean B Owen
Dec 14, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rajyalakshmi LuthraJaffer A Ajani
Jun 21, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Xifeng WuJaffer A Ajani
Sep 13, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Katja OttJörg-Rüdiger Siewert
Oct 31, 2006·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·K OttJ-R Siewert
Dec 30, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Hinrich A WiederJens Stollfuss
Feb 10, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Madan G LuthraRajyalakshmi Luthra
Feb 20, 2007·Academic Radiology·Gary J KelloffJanet Woodcock
Apr 6, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Jeremy J ErasmusStephen G Swisher
Jan 12, 2008·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Thomas B BrunnerRolf Sauer
Mar 4, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joel TepperRobert Mayer
Apr 4, 2008·Nature·Charles L Sawyers
Apr 4, 2008·Nature·Laura J van't Veer, René Bernards
Jun 25, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jaffer A AjaniChristopher G Willett
Aug 13, 2008·Journal of the National Cancer Institute·Linda Morris BrownWong-Ho Chow
Oct 8, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bruno PereiraMarc Ychou
Nov 26, 2008·Gastroenterology Clinics of North America·Peter D Siersema
Jan 24, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michelle A T HildebrandtXifeng Wu
Feb 6, 2009·Annals of Surgical Oncology·Björn L D M BrücherJaffer A Ajani
Feb 7, 2009·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·T W RiceE H Blackstone
Oct 20, 2009·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Orjan Hallberg

❮ Previous
Next ❯

Citations

May 30, 2013·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Caitlin C MurphyWayne L Hofstetter
Mar 19, 2014·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Pascaline SchollaertBruno Krug

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.