Abstract
We evaluated the roles of tumor necrosis factor (TNF)-α in alkali-induced corneal neovascularization (CNV). CNV was induced by alkali injury and compared in wild-type (WT) BALB/c mice, and TNF receptor 1-deficient (TNF-Rp55 KO) counterparts, or in mice treated with TNF-α antagonist and recombinant TNF-α. Angiogenic factor expression and leukocyte accumulation in the early phase after injury were quantified by real-time PCR and immunohistochemical analysis, respectively. Alkali injury augmented the intraocular mRNA expression of TNF-α and its receptor, together with a transient macrophage and neutrophil infiltration. Compared to WT mice, TNF-Rp55 KO mice exhibited reduced CNV. Intraocular F4/80-positive macrophages and Ly-6G-positive neutrophils infiltration did not change in KO mice compared to WT mice after the injury. Alkali injury induced a massively increased intraocular mRNA expression of angiogenic factors, including vascular endothelial growth factor (VEGF), inducible nitric oxide synthase (iNOS), interleukin (IL)-6, E-selectin, and intercellular adhesion molecule (ICAM)-1 in WT mice, whereas these increments were retarded severely in KO mice. Immunofluorescence analysis demonstrated that F4/80-positive cells expressed V...Continue Reading
Citations
Jun 7, 2013·Cornea·You Kyung Lee, Sung Kun Chung
Jun 5, 2014·BioMed Research International·Lea A KochEsther Raskopf
Oct 2, 2014·Canadian Journal of Physiology and Pharmacology·Hongyan ZhouShao Bo Su
Oct 14, 2014·Current Eye Research·Gaoqin LiuPeirong Lu
Dec 22, 2015·Ophthalmology·Apurva K PatelUNKNOWN Systemic Immunosuppressive Therapy for Eye Diseases Research Group
Mar 10, 2016·Seminars in Ophthalmology·Victoria S ChangGeorge N Papaliodis
Oct 9, 2015·Parasites & Vectors·Ji LiuZhiyue Lv
Jun 17, 2014·Experimental Eye Research·Pierfrancesco MirabelliNeil Lagali
Jun 29, 2013·Microvascular Research·Tammy L PalenskiNader Sheibani
May 16, 2015·Journal of Ethnopharmacology·Xin ChenMing Yan
May 13, 2014·Journal of Ethnopharmacology·Gang ChenChun-Hay Ko
Sep 4, 2015·PloS One·Kai HuPedram Hamrah
Aug 16, 2016·Scientific Reports·Samira KhabbaziMarie-Odile Parat
Feb 17, 2017·Acta Ophthalmologica·Fabio BignamiGiulio Ferrari
Dec 14, 2016·Microvascular Research·Deena ShresthaAndré Talvani
Feb 16, 2018·Angiogenesis·Anthony MukwayaNeil Lagali
Oct 10, 2014·Journal of Virology·Katie M Bryant-HudsonDaniel J J Carr
Mar 2, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Ann-Charlott SalabarriaFelix Bock
Jun 22, 2017·Current Eye Research·Hosoon ChoiSamuel Fulcher
Mar 10, 2015·Cornea·Jin HuangBiao Yan
Dec 17, 2014·Eye & Contact Lens·Giulio FerrariPaolo Rama
Mar 19, 2021·Ocular Immunology and Inflammation·Alireza ShahriaryHossein Aghamollaei
Jun 17, 2015·The American Journal of Pathology·Wei-Kang WuAndrew D Dick
Apr 10, 2021·PloS One·Anna-Karina B MaierAntonia M Joussen
May 4, 2021·The Ocular Surface·Shyam Sunder TummanapalliMark D P Willcox
May 15, 2021·Frontiers in Pharmacology·Xiaobing LinMing Yan
Jun 8, 2021·Progress in Retinal and Eye Research·Romina Mayra Lasagni VitarGiulio Ferrari
Jun 26, 2021·Immunopharmacology and Immunotoxicology·Melad SabzevareAlireza Shahriary
Jul 14, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Xiao-Xiao LiClara Bik-San Lau
Sep 10, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Fatma ZaguiaDebra A Goldstein