PMID: 15383581Sep 24, 2004Paper

Critical role of TNF receptor type-2 (p75) as a costimulator for IL-2 induction and T cell survival: a functional link to CD28

The Journal of Immunology : Official Journal of the American Association of Immunologists
Edward Y Kim, Hung-Sia Teh

Abstract

CD28 provides important signals that lower the threshold of T cell activation, augment the production of IL-2, and promote T cell survival. The recent identification of a second family of costimulatory molecules within the TNFR family has reshaped the "two-signal" model of T cell activation. In this study the role of p75 as a T cell costimulatory molecule in controlling cell fate during TCR/CD28-mediated stimulation was examined. We found that p75-deficient T cells possess a profound defect in IL-2 production in response to TCR/CD28-mediated stimulation. Examination of key signaling intermediates revealed that TCR proximal events such as global tyrosine phosphorylation and ZAP70 phosphorylation, as well as downstream MAPK cascades are unperturbed in p75-deficient T cells. In contrast, p75 is nonredundantly coupled to sustained AKT activity and NF-kappaB activation in response to TCR/CD28-mediated stimulation. Moreover, p75-deficient T cells possess a defect in survival during the early phase of T cell activation that is correlated with a striking defect in Bcl-x(L) expression. These data indicate discrete effects of p75 on the intracellular signaling milieu during T cell activation, and reveal the synergistic requirement of TCR...Continue Reading

References

Sep 11, 1970·Science·P Bretscher, M Cohn
Jun 1, 1995·Current Opinion in Immunology·J JainA Rao
Sep 27, 1993·Journal of Immunological Methods·S L ReinerR M Locksley
Dec 1, 1995·Molecular Reproduction and Development·R J Davis
Jan 1, 1996·Annual Review of Immunology·D J LenschowJ A Bluestone
Jan 1, 1996·Annual Review of Immunology·D Cantrell
Jun 9, 1999·Current Biology : CB·L P KaneA Weiss
Jun 22, 1999·Current Opinion in Immunology·T H Watts, M A DeBenedette
Sep 25, 1999·Seminars in Immunology·G A Holländer
Apr 27, 2000·Current Opinion in Immunology·L P KaneA Weiss
Jun 3, 2000·Annual Review of Immunology·O Acuto, D Cantrell
Sep 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·I GramagliaM Croft
Dec 12, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·E Y Kim, H S Teh
Jan 5, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Erin KellyLuk Van Parijs
Feb 28, 2002·Annual Review of Immunology·Chen DongRichard A Flavell
Mar 9, 2002·Seminars in Immunology·Doreen Cantrell
Jul 23, 2002·Trends in Immunology·Lawrence P KaneArthur Weiss
Apr 3, 2003·Immunological Reviews·Lawrence P Kane, Arthur Weiss
Apr 3, 2003·Immunological Reviews·Christopher E Rudd, Monika Raab
Jul 10, 2003·Autoimmunity Reviews·Abul K Abbas
Sep 17, 2003·Nature Reviews. Immunology·Michael Croft
Nov 18, 2003·Immunological Reviews·David M Rothstein, Mohamed H Sayegh
Jan 20, 2004·Nature Immunology·Jianxun SongMichael Croft

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Citations

Mar 22, 2006·Expert Opinion on Biological Therapy·Mario CottoneIrene Modesto
Jan 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Thomas B ThornleyDale L Greiner
Jan 5, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Melissa E Munroe, Gail A Bishop
Oct 25, 2008·BMC Medical Genomics·Min WangEleftherios T Papoutsakis
Feb 26, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Meital NagarItamar Goldstein
Jun 8, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xin ChenJoost J Oppenheim
Dec 3, 2010·PloS One·Bhavana PriyadharshiniMichael A Brehm
Aug 21, 2013·Immunological Reviews·Michael E WortzmanTania H Watts
Aug 14, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Patrick G MillerSusan C McKarns
Jun 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Huang-Ge ZhangRobert P Kimberly
Dec 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Itamar GoldsteinIlan Bank
May 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ioannis ChatzidakisClio Mamalaki
Sep 26, 2008·Clinical & Developmental Immunology·David M MillerAldo A Rossini
Oct 23, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Siwei NieLiisa K Selin
Oct 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Edward Y KimHung-Sia Teh
Nov 3, 2010·Alcoholism, Clinical and Experimental Research·Ji FanAnnette J Schlueter
Dec 6, 2014·American Journal of Physiology. Gastrointestinal and Liver Physiology·Philip E DubéD Brent Polk
Dec 11, 2014·Annual Review of Immunology·Francis Ka-Ming ChanKenta Moriwaki
Dec 5, 2015·Expert Review of Respiratory Medicine·Killian HurleyNoel G McElvaney
Aug 3, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Scott M KrummeyMandy L Ford
Oct 4, 2019·Science Translational Medicine·Eric M TamAndreas Raue
Dec 30, 2009·The Journal of Biological Chemistry·Hilka RauertHarald Wajant
Nov 10, 2007·The Journal of Clinical Investigation·Thomas CalzasciaPamela S Ohashi
May 2, 2012·Molecular and Cellular Biology·Christine RichterAnja Krippner-Heidenreich
Jun 5, 2013·International Forum of Allergy & Rhinology·Tatyana PozharskayaAndrew P Lane
Jul 26, 2016·Frontiers in Cell and Developmental Biology·Kenta MoriwakiFrancis Ka-Ming Chan
Nov 23, 2017·Frontiers in Immunology·Tobias SchmidDaniela N Männel
Jan 24, 2018·Immunology and Cell Biology·Maureen BardetFrédéric Bornancin
Jan 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Edward Y KimHung-Sia Teh
Mar 10, 2010·Immunology and Cell Biology·Maria EvangelidouLesley Probert
Jul 9, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Susan C McKarns, Ronald H Schwartz
Jan 28, 2012·Anais Brasileiros De Dermatologia·Emerson de Andrade Lima, Mariana de Andrade Lima
Mar 26, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kateryna SoloviovaCharles S Via

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