Critical roles of DNA demethylation in the activation of ripening-induced genes and inhibition of ripening-repressed genes in tomato fruit

Proceedings of the National Academy of Sciences of the United States of America
Zhaobo LangJian-Kang Zhu

Abstract

DNA methylation is a conserved epigenetic mark important for genome integrity, development, and environmental responses in plants and mammals. Active DNA demethylation in plants is initiated by a family of 5-mC DNA glycosylases/lyases (i.e., DNA demethylases). Recent reports suggested a role of active DNA demethylation in fruit ripening in tomato. In this study, we generated loss-of-function mutant alleles of a tomato gene, SlDML2, which is a close homolog of the Arabidopsis DNA demethylase gene ROS1 In the fruits of the tomato mutants, increased DNA methylation was found in thousands of genes. These genes included not only hundreds of ripening-induced genes but also many ripening-repressed genes. Our results show that SlDML2 is critical for tomato fruit ripening and suggest that active DNA demethylation is required for both the activation of ripening-induced genes and the inhibition of ripening-repressed genes.

References

Jan 23, 2003·Bioinformatics·Paul Pavlidis, William Stafford Noble
Apr 21, 2006·Proceedings of the National Academy of Sciences of the United States of America·Teresa Morales-RuizTeresa Roldán-Arjona
Jul 26, 2006·Proceedings of the National Academy of Sciences of the United States of America·Fernanda AgiusJian-Kang Zhu
Apr 20, 2007·Current Opinion in Plant Biology·James J Giovannoni
Aug 8, 2009·Annual Review of Genetics·Jian-Kang Zhu
Feb 10, 2010·Nature Reviews. Genetics·Julie A Law, Steven E Jacobsen
Oct 13, 2010·Proceedings of the National Academy of Sciences of the United States of America·Assaf ZemachDaniel Zilberman
Feb 16, 2011·Cell Research·Xin-Jian HeJian-Kang Zhu
Nov 9, 2011·Annual Review of Genetics·Harry J Klee, James J Giovannoni
Feb 14, 2012·Molecular Cell·María Isabel Martínez-MacíasJian-Kang Zhu
May 9, 2012·Bioinformatics·Elena Y HarrisStefano Lonardi
Jun 5, 2012·Nature·UNKNOWN Tomato Genome Consortium
Dec 1, 2012·Cold Spring Harbor Symposia on Quantitative Biology·H Zhang, J-K Zhu
Aug 22, 2013·Molecular Plant·Yanfei MaoJian-Kang Zhu
Apr 12, 2014·Journal of Experimental Botany·Maria Florencia CocaliadisAntonio Granell
May 9, 2014·Nature Reviews. Genetics·Marjori A Matzke, Rebecca A Mosher
Mar 4, 2015·Proceedings of the National Academy of Sciences of the United States of America·Mingguang LeiJian-Kang Zhu
Aug 12, 2015·Proceedings of the National Academy of Sciences of the United States of America·Ruie LiuPhilippe Gallusci
Nov 3, 2016·Proceedings of the National Academy of Sciences of the United States of America·Bo ZhangHarry J Klee
Dec 21, 2016·PLoS Genetics·Quentin Gouil, David C Baulcombe

❮ Previous
Next ❯

Citations

Feb 16, 2018·The Plant Journal : for Cell and Molecular Biology·Ran LiHongliang Zhu
Dec 2, 2017·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Shao-Shan C Huang, Joseph R Ecker
Nov 6, 2018·Proceedings of the National Academy of Sciences of the United States of America·Zhaobo Lang, Zhizhong Gong
Nov 13, 2018·The Plant Journal : for Cell and Molecular Biology·Christophe RothanMathilde Causse
Jan 27, 2018·Nature Communications·Yoshihito ShinozakiJocelyn K C Rose
Jul 20, 2019·Biochemical Society Transactions·Huiming ZhangJian-Kang Zhu
Oct 28, 2019·Horticulture Research·Jiemeng XuZhaobo Lang
Oct 20, 2019·Journal of Integrative Plant Biology·Ruie Liu, Zhaobo Lang
Jan 11, 2020·The Plant Journal : for Cell and Molecular Biology·Yong-Chao ZhuChang-Jie Xu
Nov 21, 2019·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Shuai SunXia Cui
Mar 13, 2020·The New Phytologist·Mohammad Reza AtighiTina Kyndt
Jan 4, 2020·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Yue LuYu Zhao
Jun 9, 2020·The New Phytologist·Dengguo TangZhaobo Lang
Jul 31, 2020·The New Phytologist·Tong ChenShiping Tian
Oct 14, 2017·Plant Cell Reports·Yan LiWeiqiang Qian
May 23, 2018·Nature Reviews. Molecular Cell Biology·Huiming ZhangJian-Kang Zhu
Dec 6, 2018·Genome Biology·Jingfei ChengZhaobo Lang
Apr 22, 2020·The Plant Journal : for Cell and Molecular Biology·Jinhua ZuoJames J Giovannoni
Jan 13, 2019·Proceedings of the National Academy of Sciences of the United States of America·Huan HuangZhaobo Lang
Nov 17, 2019·Nucleic Acids Research·Baihui WangAiwu Dong
Sep 5, 2019·Breeding Science·Taiji Kawakatsu, Joseph R Ecker
Mar 3, 2020·Frontiers in Plant Science·Jun Hyung LeeC Neal Stewart
Oct 24, 2018·Frontiers in Plant Science·Katharina Bräutigam, Quentin Cronk
Jan 9, 2019·Frontiers in Genetics·Suresh KumarTrilochan Mohapatra
Sep 25, 2019·International Journal of Molecular Sciences·Jara Teresa Parrilla-DoblasDolores Córdoba-Cañero
Oct 18, 2019·Frontiers in Plant Science·Guillaume DecrosPierre Pétriacq
Nov 28, 2017·The Plant Journal : for Cell and Molecular Biology·Lin WangHaifeng Wang
Jun 27, 2019·Horticulture Research·Tian WangHongliang Zhu
May 9, 2019·Plant Cell Reports·Chenguang WangShuifang Zhu

❮ Previous
Next ❯

Related Concepts

Related Feeds

CRISPR Ribonucleases Deactivation

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on mechanisms that underlie deactivation of CRISPR ribonucleases. Here is the latest research.

CRISPR (general)

Clustered regularly interspaced short palindromic repeats (CRISPR) are DNA sequences in the genome that are recognized and cleaved by CRISPR-associated proteins (Cas). CRISPR-Cas system enables the editing of genes to create or correct mutations. Discover the latest research on CRISPR here.

Cell Signaling & Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. This feed covers the latest research on signaling and epigenetics in cell growth and cancer.

CRISPR for Genome Editing

Genome editing technologies enable the editing of genes to create or correct mutations. Clustered regularly interspaced short palindromic repeats (CRISPR) are DNA sequences in the genome that are recognized and cleaved by CRISPR-associated proteins (Cas). Here is the latest research on the use of CRISPR-Cas system in gene editing.

Biosynthetic Transformations

Biosyntheic transformtions are multi-step, enzyme-catalyzed processes where substrates are converted into more complex products in living organisms. Simple compounds are modified, converted into other compounds, or joined together to form macromolecules. Discover the latest research on biosynthetic transformations here.

CRISPR in Cancer

CRISPR-Cas system enables the editing of genes to create or correct mutations. Given that genome instability and mutation is one of the hallmarks of cancer, the CRISPR-Cas system is being explored to genetically alter and eliminate cancer cells. Here is the latest research.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Ruie LiuPhilippe Gallusci
Proceedings of the National Academy of Sciences of the United States of America
Fernanda AgiusJian-Kang Zhu
Biochemical and Biophysical Research Communications
Hosung JangJin Hoe Huh
The Arabidopsis Book
Mary Gehring, Steven Henikoff
© 2022 Meta ULC. All rights reserved