Critical roles of FAM134B in ER-phagy and diseases.

Cell Death & Disease
Jie MoBi-Xiang Zhang

Abstract

FAM134B (also called JK-1, RETREG1), a member of the family with sequence similarity 134, was originally discovered as an oncogene in esophageal squamous cell carcinoma. However, its most famous function is that of an ER-phagy-regulating receptor. Over the decades, the powerful biological functions of FAM134B were gradually revealed. Overwhelming evidence indicates that its dysfunction is related to pathophysiological processes such as neuropathy, viral replication, inflammation, and cancer. This review describes the biological functions of FAM134B, focusing on its role in ER-phagy. In addition, we summarize the diseases in which it is involved and review the underlying mechanisms.

References

Oct 29, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·J H Teckman, D H Perlmutter
Oct 5, 2001·Nature Reviews. Molecular Cell Biology·P Cohen, S Frame
May 4, 2002·Nature Reviews. Molecular Cell Biology·Mariann Bienz
Oct 17, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jeffrey H TeckmanDavid H Perlmutter
Jan 17, 2003·Molecular and Cellular Biology·Leanne Wilson-FritchSilvia Corvera
Sep 16, 2004·Current Opinion in Neurology·Henry HouldenMary M Reilly
May 4, 2005·The Journal of Cell Biology·Masaaki KomatsuTomoki Chiba
Jul 21, 2005·Molecular Biology of the Cell·Rebecca A GreenKenneth B Kaplan
Aug 12, 2006·Cell·Yoko ShibataTom A Rapoport
Dec 1, 2007·Proceedings of the National Academy of Sciences of the United States of America·Rachel L SchweersPaul A Ney
Apr 22, 2009·Cell Host & Microbe·Sonja WelschRalf Bartenschlager
Sep 3, 2010·Nature Cell Biology·Claudine KraftKay Hofmann
Dec 1, 2010·Journal of Neurology, Neurosurgery, and Psychiatry·Sinéad M MurphyMary M Reilly
Dec 24, 2010·Nature Reviews. Molecular Cell Biology·Richard J Youle, Derek P Narendra
Jan 13, 2011·Virology Journal·Suchita Bhattacharyya, Thomas J Hope
Jan 22, 2011·Autophagy·Ke Wang, Daniel J Klionsky
Mar 18, 2011·Nature·Marcus E Peter
Nov 15, 2011·Cell·Noboru Mizushima, Masaaki Komatsu
Jan 19, 2012·Nature Reviews. Molecular Cell Biology·Claudio Hetz
Dec 12, 2012·Cell·Jeffrey L Brodsky
Feb 9, 2013·Journal of Innate Immunity·Xiaonan Dong, Beth Levine
Jun 19, 2013·Biochimica Et Biophysica Acta·Vassiliki NikoletopoulouNektarios Tavernarakis
Nov 10, 2013·Nature Reviews. Molecular Cell Biology·Christopher A LambSharon A Tooze
Mar 13, 2014·The Journal of Cell Biology·Budhaditya BanerjeeP Todd Stukenberg

❮ Previous
Next ❯

Citations

May 1, 2021·Molecular Cell·Laura Martin-SanchoSumit K Chanda
Apr 8, 2021·Molecular Biology of the Cell·Darshan KumarEija Jokitalo

❮ Previous
Next ❯

Methods Mentioned

BETA
ubiquitination

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.