PMID: 8980013Apr 1, 1995Paper

Critical values for plasma glucose in aggravating ischaemic brain damage: correlation to extracellular pH

Neurobiology of Disease
P A LiB K Siesjö

Abstract

The objective of the present experiments was to characterize conditions under which pre-ischaemic hyperglycaemia aggravates brain damage following transient forebrain ischaemia. Specifically, we wished to explore whether accentuated damage is a threshold function of plasma glucose concentration or pH, as assessed by measurements of extracellular pH (pHe). Forebrain ischaemia of 10 min duration was induced in rats at varying degrees of hyperglycaemia, with continuous measurements of pHe, and the animals were allowed to survive for 7 days before histopathological evaluation of the density and distribution of brain damage. Ischaemic brain damage appeared as a threshold function of plasma glucose concentration. At values of 4-6 mM virtually no damage was observed in any other structure than the CA1 sector of the hippocampus and, even in that structure, damage was variable. At glucose concentrations of 8-12 mM moderate damage was observed infrequently in caudoputamen, parietal cortex, and thalamus. At values above 12 mM, damage increased dramatically in these areas, and additional structures were recruited in the damage process (cingulate cortex, the CA3 sector of the hippocampus, and substantia nigra). Measurements of pHe in pariet...Continue Reading

Citations

Mar 17, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·L GisselssonB K Siesjö
May 3, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P A LiJ P MacManus
Dec 25, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Anna RytterTadeusz Wieloch
Oct 3, 1999·Physiological Reviews·P Lipton
Jan 2, 2003·Annals of Neurology·Evan M SchwechterLibor Velísek
Aug 13, 2005·Acta Anaesthesiologica Scandinavica·T KimuraY Masaki
Nov 3, 2011·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Lokesh K Bhatt, Veeranjaneyulu Addepalli
Aug 21, 2019·BioMed Research International·Anna Rorbach-Dolata, Agnieszka Piwowar
Apr 25, 2001·Journal of the American Veterinary Medical Association·R S SyringK J Drobatz
Oct 30, 2007·Nature Neuroscience·David J RossiClaudia Mohr
Mar 26, 2003·Intensive Care Medicine·Pedro Diaz-ParejoCarl-Henrik Nordström
Mar 8, 2013·Science Translational Medicine·Rosa FerrieroNicola Brunetti-Pierri
Feb 6, 2010·Journal of Neurochemistry·Jan LewerenzPamela Maher
Jul 22, 2014·Journal of Neuroscience Research·Zhigang LeiZao C Xu
Dec 16, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H UchinoZ Kokaia
Feb 14, 2004·Stroke; a Journal of Cerebral Circulation·Tobias CronbergTadeusz Wieloch
Jan 8, 2000·Stroke; a Journal of Cerebral Circulation·P A LiD S Warner
Jun 18, 2005·Brain Research. Molecular Brain Research·Marianna MuranyiPing-An Li

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