Critical Windows of Cardiovascular Susceptibility to Developmental Hypoxia in Common Snapping Turtle (Chelydra serpentina) Embryos

Physiological and Biochemical Zoology : PBZ
Kevin B TateDane A Crossley

Abstract

Environmental conditions fluctuate dramatically in some reptilian nests. However, critical windows of environmental sensitivity for cardiovascular development have not been identified. Continuous developmental hypoxia has been shown to alter cardiovascular form and function in embryonic snapping turtles (Chelydra serpentina), and we used this species to identify critical periods during which hypoxia modifies the cardiovascular phenotype. We hypothesized that incubation in 10% O2 during specific developmental periods would have differential effects on the cardiovascular system versus overall somatic growth. Two critical windows were identified with 10% O2 from 50% to 70% of incubation, resulting in relative heart enlargement, either via preservation of or preferential growth of this tissue, while exposure to 10% O2 from 20% to 70% of incubation resulted in a reduction in arterial pressure. The deleterious or advantageous aspects of these embryonic phenotypes in posthatching snapping turtles have yet to be explored. However, identification of these critical windows has provided insight into how the developmental environment alters the phenotype of reptiles and will also be pivotal in understanding its impact on the fitness of egg...Continue Reading

References

Sep 1, 1977·Respiration Physiology·R A Ackerman
Jan 1, 1988·Respiration Physiology·J W Dusseau, P M Hutchins
Sep 1, 1995·The Journal of Experimental Zoology·S J WarburtonT Wang
Mar 19, 2002·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Edward M DzialowskiWarren W Burggren
Dec 21, 2002·Evolution & Development·Sonia E Sultan
Nov 1, 1958·The American Journal of Anatomy·C T GRABOWSKI, J A PAAR
Jul 23, 2004·Nature·Patrick BatesonSonia E Sultan
Mar 12, 2005·The Journal of Physiology·L DavisG D Giraud
May 30, 2006·The Journal of Experimental Biology·Theodore Garland, Scott A Kelly
May 19, 2010·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Chiu-Lin ChenI-Jiunn Cheng
Jul 30, 2011·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·John EmeDane A Crossley
Apr 10, 2012·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Kevin B TateDane A Crossley
Sep 3, 2013·Physiological and Biochemical Zoology : PBZ·Elizabeth F JohnstonTodd E Gillis
Feb 28, 2014·The Journal of Experimental Biology·Edwin W TaylorDane A Crossley
Feb 1, 2013·Journal of Developmental Origins of Health and Disease·E A HerreraD A Giussani

❮ Previous
Next ❯

Citations

Dec 17, 2014·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·John Eme, Dane A Crossley
Oct 28, 2016·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Dane A CrossleyJohn Eme
May 13, 2017·The Journal of Experimental Biology·Oliver H WearingDane A Crossley
Dec 20, 2015·The Journal of Experimental Biology·Casey A MuellerWarren W Burggren
Jan 31, 2018·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Derek NelsonKevin B Tate
Feb 11, 2020·Frontiers in Physiology·Warren W Burggren
May 3, 2016·Integrative Zoology·Gerardo A CorderoEric J Gangloff
Nov 27, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Oliver H WearingDane A Crossley
Apr 22, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kevin B TateDane A Crossley
Mar 20, 2021·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Alexander G LittleChristopher D Moyes
Mar 21, 2021·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Alexander G LittleChristopher D Moyes
Mar 30, 2021·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Alexander G LittleChristopher D Moyes
May 14, 2021·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·John EmeDane A Crossley
Jul 16, 2021·Frontiers in Physiology·Gina L J GalliDane A Crossley
Jul 6, 2021·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Renato FilogonioDane A Crossley
Oct 28, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Naim M BautistaAngela Fago

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.