PMID: 11911439Mar 26, 2002Paper

Critically assessing the state-of-the-art in protein structure prediction

The Pharmacogenomics Journal
David T Jones

Abstract

One of the most tantalising 'grand challenges' in structural biology is to solve the problem of predicting the structure of a protein from its amino acid sequence alone. Although this problem appeals to many researchers on a purely academic level, the practical importance of protein structure prediction has become particularly clear with the release of the first draft of the complete human genome sequence last year. This moved modern biology into the new so-called 'post genome' era, and for the foreseeable future, one of the main issues in modern biology will be the characterisation of the many 'unknown' gene sequences which are now sitting waiting in DNA and protein data banks. Protein structure can provide a great deal of insight into the evolutionary origins, function and mechanism of a protein, and so any means for determining the 3-D structure of a novel protein will likely be of critical importance.

References

Aug 11, 1995·Journal of Molecular Biology·A AszódiW R Taylor
Feb 1, 1995·Nature Structural Biology·D Shortle
Nov 1, 1995·Proteins·B Rost, C Sander
Feb 1, 1997·Nature Structural Biology·D Eisenberg
Sep 1, 1997·Nucleic Acids Research·S F AltschulD J Lipman
Dec 24, 1997·Environmental Health Perspectives·Q RahmanM Athar
Jan 27, 1999·Bioinformatics·S R Eddy
Feb 27, 1999·Nature Structural Biology·P Koehl, M Levitt
May 17, 2000·Proceedings of the National Academy of Sciences of the United States of America·M M YoungG Dollinger
Feb 24, 2001·Journal of Biomolecular NMR·P M BowersD Baker

❮ Previous
Next ❯

Citations

May 21, 2005·Biophysical Chemistry·M Michael Gromiha
Jan 28, 2003·Current Opinion in Chemical Biology·Alejandro Giorgetti, Paolo Carloni
Aug 22, 2007·BMC Bioinformatics·Yungki ParkVolkhard Helms
Apr 17, 2008·BMC Genomics·Jack Y YangXudong Huang
Oct 26, 2005·Biopolymers·Wenqi Huang, Jingfa Liu
Nov 6, 2004·Nature Biotechnology·Karl A Thiel
Mar 28, 2007·Home Health Care Services Quarterly·Jeanne Geiger-BrownAlison Trinkoff
Jul 3, 2007·SAHARA J : Journal of Social Aspects of HIV/AIDS Research Alliance·D Skinner, S Mfecane

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.