CRM1/XPO1 expression in pancreatic adenocarcinoma correlates with survivin expression and the proliferative activity

Oncotarget
David M SaulinoMamoun Younes

Abstract

CRM1/XPO1 (CRM1) is a nuclear export chaperone that mediates the export of proteins essential to growth regulation and tumor suppression. Its overexpression in tumors was found to be associated with poor prognosis. Selective inhibitors of nuclear export are in phase I and II clinical trials for several tumor types. Our aim was to investigate CRM1 expression in pancreatic adenocarcinoma (PAC) and its relationship to survivin expression and the proliferative activity. Sections of tissue microarray containing 76 formalin fixed and paraffin embedded PAC were stained by immunohistochemistry (IHC) for CRM1, survivin, and Cyclin A. Expression levels of CRM1 and survivin and the proliferative activity, the S-phase fraction (SPF) in tumor cells, were determined using a quantitative digital image analysis solution (OTMIAS). Sixty-six of the 76 (86%) PAC showed positive staining for CRM1, and 10 (14%) were completely negative. The mean CRM1 expression levels ranged from 0.3 to 53 units and the median from 0.3 to 45 units. There was significant positive correlation between the mean and median expression levels of CRM1 in tumor cells and the mean and median levels of survivin (p<0.001). Moreover, there was positive correlation between the m...Continue Reading

References

Aug 10, 2004·Surgery·Kazuhiro KamiMasayuki Imamura
Jun 30, 2005·International Journal of Cancer. Journal International Du Cancer·Hiroya TakeuchiDave S B Hoon
Oct 6, 2005·BMC Cancer·Myung Ah LeeSeung-Nam Kim
Nov 14, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shirley K KnauerRoland H Stauber
Apr 9, 2013·Blood·Kensuke KojimaMichael Andreeff
Mar 11, 2015·Therapeutic Advances in Medical Oncology·Andrea TeagueAndrea Wang-Gillam
May 29, 2015·World Journal of Surgical Oncology·He DongWei Feng
Jul 18, 2015·Biologics : Targets & Therapy·Salma KhanNathan R Wall
Sep 25, 2015·Cells·Achim DickmannsRalf Ficner
Feb 27, 2016·Journal of Cancer·Xun ChenWentao Zhang
Mar 2, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Albiruni R Abdul RazakAmit Mahipal
Sep 21, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ying ChenJohn A Martignetti
Nov 1, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Thomas VercruysseDirk Daelemans
Jan 6, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Jul 3, 2017·Translational Oncology·Barbara MuzAbdel Kareem Azab
Jul 1, 2016·Signal Transduction and Targeted Therapy·Qingxiang SunDa Jia
Jan 31, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dan T VoglA Keith Stewart

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Citations

May 6, 2019·Journal of Clinical Medicine·David Jérémie BirnbaumFrançois Bertucci
Feb 1, 2019·Oncotarget·Mamoun YounesJennifer M Bailey
Jun 4, 2020·Journal of Hematology & Oncology·Nancy G Azizian, Yulin Li
Nov 12, 2020·Nature Reviews. Clinical Oncology·Asfar S AzmiRamzi M Mohammad

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