Crocin Attenuates Oxidative Stress and Myocardial Infarction Injury in Rats

International Heart Journal
Yongwang WangHongyin Du

Abstract

Oxidative stress and excessive nitric oxide (NO) production play considerable roles in infarction-induced injury impairing cardiac functions. Crocin is the active constituent of Crocus sativus (saffron) with antioxidant properties and has protective effects against disturbances induced by ischemia in many organs. The present study aimed to investigate the protective effects and the underlying mechanisms of crocin on myocardial infarction (MI)-induced injury in rats in vivo. MI rats were intraperitoneally injected with crocin at different doses for seven successive days after coronary ligation. Infarct size, hemodynamic studies, and capillary density were evaluated. Levels of oxidative stress, inducible nitric oxide synthase (iNOS), endothelial nitric oxide synthase (eNOS), and their corresponding phosphorylation expressions were then measured. Crocin decreased infarct size, left ventricular (LV) end-diastolic pressure, and LV minimum dP/dt while increased LV maximum dP/dt and percentage of LV fractional shortening dose dependently. Capillary density was markedly increased after crocin treatment. Crocin enhanced superoxide dismutase activity and reduced malondialdehyde levels as well as inhibited excessive production of NO throu...Continue Reading

References

Jan 1, 1978·Methods in Enzymology·J A Buege, S D Aust
Apr 6, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·N NagayaK Kangawa
Dec 1, 2005·Phytotherapy Research : PTR·A N AssimopoulouV P Papageorgiou
May 25, 2007·Archives of Physiology and Biochemistry·Alexander V OvechkinAndrew M Roberts
Oct 29, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·Hossein HosseinzadehZahra Saffari
Feb 11, 2009·Antioxidants & Redox Signaling·Hajime Otani
Nov 3, 2010·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Alireza Timcheh HaririHossein Hosseinzadeh
Jul 28, 2011·The Open Cardiovascular Medicine Journal·Sanja S SoskićEsma R Isenović
Dec 10, 2015·Arquivos brasileiros de cardiologia·Paula S AzevedoLeonardo A M Zornoff
May 28, 2016·Chonnam Medical Journal·JongUn LeeSoo Wan Kim
Sep 23, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Palaniyandi Akila, Lakshmanan Vennila
Dec 14, 2016·Journal of Cellular and Molecular Medicine·Melissa Christine KanderZhenguo Liu
May 10, 2017·International Heart Journal·Xingxing WangRuibing Su

❮ Previous
Next ❯

Citations

Nov 2, 2019·Pharmacological Reports : PR·Vafa Baradaran RahimVahid Reza Askari
Dec 29, 2020·Critical Reviews in Food Science and Nutrition·Débora Cerdá-BernadMaría José Frutos
Feb 18, 2021·Psychopharmacology·Ying YangYuanyuan Cheng
Feb 1, 2020·Pharmacological Reports : PR·Vafa Baradaran RahimVahid Reza Askari
Mar 15, 2021·Environmental Science and Pollution Research International·Shenhao ZhuZengjun Wang

❮ Previous
Next ❯

Related Concepts