Crocin enhances hypothermia therapy in hypoxic ischemia-induced brain injury in mice.

Acta neurologica Belgica
Anqi Huang, Lihua Jia

Abstract

Hypoxic-ischemic encephalopathy (HIE) is a serious medical situation at labor which leads to severe brain damage. Hypothermia therapy is the standard treatment for infants with HIE, but the efficacy is limited. Combination treatments are considered to enhance the efficacy of hypothermia. Crocin is an extract from saffron which has anti-inflammatory, anti-oxidant, and neuroprotective properties. The present study sought to investigate whether crocin could act as a combined treatment with hypothermia in a mouse model of HIE. C57BL/6J mice at post-natal day 7 were subjected to left common carotid artery ligation, followed by treatment of crocin (10 mg/kg) and hypothermia, either alone or in combination. Brain edema and tissue infarct were measured to evaluate brain damage. Mediators involved in inflammatory response and oxidative stress were measured. Neurological severity score test was performed to evaluate the functional outcome. Results show that crocin treatment alone could reduce inflammation and brain damage after hypoxia-ischemia. Combined treatment of crocin and hypothermia exerted enhanced therapeutic effect compared with single treatment, resulting in significantly less brain damage, reduced inflammatory and oxidative r...Continue Reading

References

Jul 1, 1997·Acta Paediatrica. Supplement·H HagbergM Puka-Sundvall
Nov 5, 2004·The New England Journal of Medicine·Donna M Ferriero
Sep 15, 2010·Pediatric Neurology·Serafina PerroneGiuseppe Buonocore
Sep 20, 2011·Newborn and Infant Nursing Reviews : NAINR·Kimberly A Allen, Debra H Brandon
Jan 2, 2013·Paediatrics & Child Health·Abraham Peliowski-Davidovich, UNKNOWN Canadian Paediatric Society, Fetus and Newborn Committee
Feb 27, 2013·The Cochrane Database of Systematic Reviews·Susan E JacobsPeter G Davis
Jul 31, 2013·Acta Pharmacologica Sinica·Fudong Liu, Louise D McCullough
Sep 11, 2014·Clinical and Experimental Immunology·H O EliwanE J Molloy
Mar 25, 2015·Developmental Medicine and Child Neurology·Bobbi FleissPierre Gressens
Oct 7, 2015·Frontiers in Neurology·Joanne O DavidsonAlistair J Gunn
Aug 31, 2018·Brain : a Journal of Neurology·Eridan Rocha-FerreiraAhad A Rahim

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Citations

Apr 8, 2020·Journal of Psychopharmacology·Patrícia Maidana MiguelLenir Orlandi Pereira
Sep 25, 2020·Antioxidants·Hanna KletkiewiczJustyna Rogalska
Jan 21, 2021·International Journal of Molecular Sciences·Hadi MohsenpourMohammad Hosein Farzaei
Mar 23, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Shakiba AzamiFatemeh Forouzanfar

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