PMID: 6965794Jan 1, 1980Paper

Crohn disease lymph node homogenates produce murine lymphoma in athymic mice

Proceedings of the National Academy of Sciences of the United States of America
K M DasR Morecki

Abstract

To study the putative agent(s) related to Crohn disease, we intraperitoneally in injected mesenteric lymph node homogenates from four patients with active Crohn disease into 10-week-old athymic (nu/nu) mice. Control mice (nu/nu) were injected with homogenates of mesenteric lymph nodes from two patients with ulcerative colitis and four patients undergoing elective cholecystectomy, and with a homogenate of a cervical lymph node containing sarcoid granuloma. Thirty-four mice received filtered or unfiltered homogenates from Crohn disease lymph nodes. Thirty-two mice received homogenates or filtrates from lymph nodes of control patients. Four mice from the group injected with Crohn disease homogenates from four different patients developed generalized lymphadenopathy due to lymphoma 10-28 weeks after th injection. Two additional mice developed lymphadenopathy due to plasma cell hyperplasia. None of the control mice developed lymphomas or lymphadenopathy. Two lymphomas were homogenized, filtered, and injected intraperitoneally into a second group of nu/nu mice, which also developed lymphoma within 8 weeks of injection. Two lymphomas were cultured in vitro and B cell sur?ACE MARKERS WERE IDENTIFIED. Indirect immunofluorescence studies...Continue Reading

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Citations

Nov 1, 1986·Journal of Clinical Immunology·W Strober, S P James
Jun 1, 1982·Digestive Diseases and Sciences·S B HanauerJ B Kirsner
Dec 1, 1985·Digestive Diseases and Sciences·W Strober
Apr 1, 1985·Digestive Diseases and Sciences·J A GirónA Durántez
Jul 27, 2001·Alimentary Pharmacology & Therapeutics·G P Aithal, J C Mansfield
Apr 8, 1982·The New England Journal of Medicine·J B Kirsner, R G Shorter
Aug 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·G BeattieN O Kaplan
Mar 19, 2003·Journal of Clinical Gastroenterology·Calvin H Hall, Mohamad Shamma
Oct 8, 2013·Journal of Crohn's & Colitis·Daniel J MulderJacalyn M Duffin
Jan 1, 1981·Virchows Archiv. A, Pathological Anatomy and Histology·J ThybergP Klingenström
Jul 1, 1983·The American Journal of the Medical Sciences·M R SimonB B Williams
Jun 1, 1981·Medical Hypotheses·H Nyhlin, M A Eastwood
Mar 1, 1991·Veterinary Pathology·H L HamiltonC J Czuprynski
Aug 17, 2001·European Journal of Gastroenterology & Hepatology·C W TanD R Shreeve
Feb 6, 1999·The American Journal of Gastroenterology·G ParasherK Iswara
Jan 1, 1989·Infection and Immunity·H L HamiltonC J Czuprynski

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