PMID: 9431906Feb 12, 1998Paper

Crohn's disease and sarcoidosis: systemic granulomatosis?

European Journal of Gastroenterology & Hepatology
K FellermannE F Stange

Abstract

We report an unusual case of severe Crohn's disease with involvement of the lung. In 1993 at age 21 a male patient experienced a Helicobacter-negative duodenitis. A routine chest radiograph revealed spotted opacities in the right upper lobe without discomfort and normal pulmonary function except for a reduced diffusion capacity. Bronchoalveolar lavage showed mild lymphocytosis and biopsies from the macroscopically normal bronchi displayed non-caseating granulomas. In 1995 he had symptoms of peptic ulcer disease with a gastric outlet stenosis. He underwent Billroth I resection with only temporary improvement. Three months later the symptoms had recurred and a stenosing inflammatory process of the duodenum was seen on endoscopy suggesting Crohn's disease. A chest radiograph demonstrated infiltrations in parts of the left lung and bronchoalveolar lavage again revealed alveolar lymphocytosis (CD4/CD8 ratio 3.1). Both the gastrointestinal and pulmonary affections responded to corticosteroids but the duodenal stricture had to be resected. The association of Crohn's disease and pulmonary disorders is discussed.

Citations

Dec 3, 2010·Journal of Crohn's & Colitis·Giovanni CasellaGabrio Bassotti
Jun 14, 2005·Genes and Immunity·M C IannuzziB A Rybicki
Apr 30, 2002·Inflammatory Bowel Diseases·Nizar N RamzanMichael S Shapiro
May 29, 2003·Inflammatory Bowel Diseases·Ian StorchSeymour Katz
Nov 17, 1998·American Journal of Respiratory and Critical Care Medicine·O VandenplasE Marchand
Mar 11, 2000·American Journal of Respiratory and Critical Care Medicine·A MansiF Santamaria
Jan 15, 2014·World Journal of Gastroenterology : WJG·De-Gan LuCai-Qing Zhang
Feb 28, 2002·The American Journal of Gastroenterology·K R HerrlingerK Fellermann
Jan 6, 2007·Journal of Pediatric Gastroenterology and Nutrition·Rodney D BoyumPhilip L Rogers
Mar 10, 2000·The American Journal of Gastroenterology·Z FiremanE Fireman
Oct 16, 2008·The American Journal of Gastroenterology·Ellen C EbertKlaus D Hagspiel
Oct 14, 2014·World Journal of Gastroenterology : WJG·Xiao-Qing JiDe-Gan Lu
Oct 12, 2019·Journal of Crohn's & Colitis·Elena EliadouUNKNOWN ECCO CONFER COMMITTEE
Jun 1, 2004·Inflammatory Bowel Diseases·Hiroaki OmoriKazuyoshi Saito
Aug 29, 2006·World Journal of Gastroenterology : WJG·Katja S RothfussKlaus R Herrlinger
May 27, 2008·Medicina clínica·Pedro Emilio Bermejo, Aurora Burgos

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