Crohn's disease and smoldering multiple myeloma: a case report and literature review

Intestinal research
So Young ParkHyo Jong Kim

Abstract

Crohn's disease (CD) is a chronic inflammatory bowel disease (IBD) that presents with abdominal pain, weight loss, and diarrhea. Although the etiology has not been fully elucidated, both environmental and genetic causes are known to be involved. In chronic inflammatory conditions such as IBD, B lymphocytes are chronically stimulated, and they induce monoclonal expansion of plasma cells, sometimes resulting in monoclonal gammopathy of undetermined significance. Immunomodulators that are commonly used to control inflammation, such as tumor necrosis factor-α (TNF-α) blockers could increase the possibility of hematologic malignancy. The pathogenesis of multiple myeloma in association with TNF-α inhibitor therapy is attributed to decreased apoptosis of plasma cell populations. Here, we describe a case of a 36-year-old male patient who was diagnosed with immunoglobulin A subtype smoldering multiple myeloma during the treatment for CD with infliximab and adalimumab. We report this case along with a review of the literature on cases of multiple myeloma that occurred in conjunction with CD.

References

Jan 1, 1990·Digestion·H NakajimaY Yoshida
Dec 1, 1980·British Journal of Haematology·A Carter, I Tatarsky
Oct 27, 1999·Journal of Gastroenterology·A MinamiS Miura
Dec 5, 2002·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·Hugh J Freeman
Apr 11, 2007·Digestive Diseases and Sciences·G Joel ReynoldsWillem J S de Villiers
Aug 25, 2007·Digestive Diseases and Sciences·Hong Liu, Jan S Moreb
Feb 28, 2008·Nature Clinical Practice. Rheumatology·Frank Mielke, Marcus Schweigert
Nov 23, 2011·Clinical and Experimental Dermatology·M S ShareefA S Highet
Dec 3, 2014·The Lancet Oncology·S Vincent RajkumarJesus F San Miguel

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Citations

Sep 23, 2021·Blood Advances·Ilseyar AkhmetzyanovaDavid Fooksman

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Methods Mentioned

BETA
electrophoresis
biopsy

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