Crohn's disease-induced non-alcoholic fatty liver disease (NAFLD) sensitizes for severe acute hepatitis B infection and liver failure

Zeitschrift für Gastroenterologie
Ali CanbayGuido Gerken

Abstract

Non-alcoholic fatty liver disease (NAFLD) commonly is associated with chronic inflammatory bowel disease (CIBD) and usually is considered to be stable and benign. However, NAFLD -- and in particular its subset, non-alcoholic steatohepatitis (NASH) -- may lead to progressive liver disease. Moreover, NAFLD sensitizes the liver to injury and increases the risk of developing acute-on-chronic liver failure following a "third hit". We here present one patient with NASH, as probably induced by long-standing Crohn's disease in the absence of ethanol consumption or abuse. The patient acquired an acute HBV infection and died from complications. As based on the clinical and histological findings, Crohn's disease appears to be a risk factor for developing NAFLD and thus to contribute to the progression into NASH. In conclusion, we suggest that Crohn's disease-related NAFLD may increase the vulnerability of the liver, which indicates that patients with a known history of CIBD merit special attention.

Citations

Jan 29, 2008·Journal of Pediatric Gastroenterology and Nutrition·Folashade A Jose, Melvin B Heyman
Jul 2, 2011·Lipids in Health and Disease·Mei MeiXiong Z Ruan
Feb 2, 2008·World Journal of Gastroenterology : WJG·Madhusudana Girija Sanal
Dec 3, 2010·Journal of Crohn's & Colitis·Konstantinos H KatsanosUNKNOWN Northwest Greece IBD Study Group
Aug 30, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kun L MaZac Varghese
Apr 1, 2010·Journal of the Science of Food and Agriculture·Jang-Woo ShinChang-Gue Son
Dec 8, 2010·Proteomics. Clinical Applications·Maria Paola Simula, Valli De Re
May 22, 2013·American Journal of Clinical Pathology·Flavia G N Rosado, Annette S Kim
Nov 22, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Hans L TillmannGeorge N Dalekos
Apr 6, 2019·Current Medicinal Chemistry·Shahram GolbabapourBita Geramizadeh
Jun 5, 2007·Clinics in Liver Disease·Eve A Roberts

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