Crohn's disease of the vulva: A prospective study

Journal of Gastroenterology and Hepatology
Bevin Bhoyrul, Calum Lyon

Abstract

Vulval Crohn's disease (VCD) is a rare extra-intestinal cutaneous manifestation of Crohn's disease. VCD is often unrecognized and misdiagnosed and can be difficult to treat. The aim of the study was to describe the clinical presentation, associated features, and response to treatment modalities in patients with VCD. A prospective review of patients with VCD who were referred to our specialist dermatology clinic from 2003 to 2017 was performed. Data on age at diagnosis, presenting signs, associated features, and response to treatment were collected. Thirty-one patients with a median age of 40 years (range 13-66 years) were identified. VCD manifested most frequently with vulval edema (77%), ulceration (35%), and fissures (39%). Eighty-one percent had active gastrointestinal disease. Oral involvement and pyoderma gangrenosum were present in 13% and 19%, respectively. Topical therapy was effective in mild VCD. Tumor necrosis factor-α inhibitors were the most effective second-line therapy, with 53% achieving complete clinical remission. Additionally, we have found compression garments and shorts to be useful adjuncts in treating vulval edema. Vulval Crohn's disease is a diagnostic and therapeutic challenge. We recommend consideratio...Continue Reading

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Citations

Jun 30, 2019·Journal of Cutaneous Medicine and Surgery·Khalad MaliyarAfsaneh Alavi
Nov 7, 2019·The American Journal of Dermatopathology·Debajyoti ChatterjeeBishan D Radotra
May 23, 2019·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Andrea Schmitt, Andreas Volz
May 23, 2019·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Andrea Schmitt, Andreas Volz
Aug 28, 2019·La Revue de médecine interne·J CastagnaF Pelletier
Jun 9, 2020·Annales de dermatologie et de vénéréologie·C CanardM Viguier
Aug 26, 2021·Indian Dermatology Online Journal·Debajyoti ChatterjeeUma Nahar Saikia
Apr 27, 2021·International Journal of Women's Dermatology·Bridget E ShieldsRachel Kornik

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