Cronkhite-Canada Syndrome Associated with Gastric Outlet Obstruction and Membranous Nephropathy: A Case Report and Review of the Literature.

Internal Medicine
Yusuke OnozatoYoshiyuki Ueno

Abstract

A 47-year-old man presented with dysgeusia, anorexia, and diarrhea. An endoscopic evaluation showed widespread gastrointestinal nodular inflammation and polyps. The pathological findings were consistent with Cronkhite-Canada Syndrome (CCS). Prednisolone therapy resulted in clinical improvement. However, CCS relapse complicated with gastric obstruction was observed during drug tapering. Although his symptoms disappeared after the reintroduction of steroids, he developed membranous nephritis. Additional cyclosporine A (CyA) treatment dramatically improved his proteinuria and residual gastrointestinal polyposis. The clinical symptoms resolved with steroid treatment, while CyA was effective for both CCS lesions and membranous nephropathy. CyA might therefore be a potential treatment option for CCS associated with membranous nephropathy.

References

Jun 16, 1955·The New England Journal of Medicine·L W CRONKHITE, W J CANADA
Sep 9, 2005·European Journal of Gastroenterology & Hepatology·Piero VerniaAlessandro Pierucci
May 19, 2007·Digestion·Douglas L Riegert-JohnsonLisa A Boardman
Aug 2, 2008·The Surgical Clinics of North America·Daniel Calva, James R Howe
Jun 30, 2009·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Hideaki KarasawaIwao Sasaki
Jul 3, 2009·The New England Journal of Medicine·Laurence H BeckDavid J Salant
Sep 2, 2011·Digestive Diseases and Sciences·Seth SweetserLisa A Boardman
Mar 1, 2012·Nature Reviews. Nephrology·Pierre Ronco, Hanna Debiec
Dec 27, 2013·Gastroenterology Research and Practice·Marcela KopáčováIlja Tachecí
Feb 26, 2016·BMC Gastroenterology·Ruifeng ZhaoLiangru Zhu
Dec 13, 2018·Frontiers in Immunology·Jae-Ung LeeJe-Min Choi
Jan 16, 2019·Case Reports in Nephrology and Dialysis·Christine FirthLeslie F Thomas
Oct 18, 2019·ACG Case Reports Journal·Eric J MaoSean Fine

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BETA
biopsy
biopsies

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