Cross-β amyloid nanotubes for hydrolase-peroxidase cascade reactions.

Chemical Communications : Chem Comm
Ayan ChatterjeeDibyendu Das

Abstract

Herein, we report the catalytic potential of short peptide based cross-β amyloid nanotubes with surface exposed histidine capable of binding hemin and showing facile cascade reactions, playing the dual roles of hydrolases and peroxidases, two of the most important classes of enzymes in extant biology. The activity of these simple systems exceeded those of modern and larger proteins like cytochrome C and hemoglobin. Further, evidence suggested that these self-assembled nanotubes foreshadow the process of intermediate channeling, a feature seen in the case of advanced enzymes.

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Citations

Sep 22, 2020·Angewandte Chemie·Ayan ChatterjeeDibyendu Das
Dec 2, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Katherine BobackJillian E Smith-Carpenter
Feb 19, 2021·Soft Matter·Valeria CastellettoIan W Hamley
Jan 19, 2021·Chemistry : a European Journal·Oleksii ZozuliaIvan V Korendovych
Jul 20, 2021·Chemical Communications : Chem Comm·Sumit PalDibyendu Das
Aug 24, 2021·Current Opinion in Chemical Biology·Liam R Marshall, Ivan V Korendovych

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