Cross-Border Movement of Highly Drug-Resistant Mycobacterium tuberculosis from Papua New Guinea to Australia through Torres Strait Protected Zone, 2010-2015

Emerging Infectious Diseases
Arnold BainomugisaChristopher Coulter

Abstract

In this retrospective study, we used whole-genome sequencing (WGS) to delineate transmission dynamics, characterize drug-resistance markers, and identify risk factors of transmission among Papua New Guinea residents of the Torres Strait Protected Zone (TSPZ) who had tuberculosis diagnoses during 2010-2015. Of 117 isolates collected, we could acquire WGS data for 100; 79 were Beijing sublineage 2.2.1.1, which was associated with active transmission (odds ratio 6.190, 95% CI 2.221-18.077). Strains were distributed widely throughout the TSPZ. Clustering occurred more often within than between villages (p = 0.0013). Including 4 multidrug-resistant tuberculosis isolates from Australia citizens epidemiologically linked to the TSPZ into the transmission network analysis revealed 2 probable cross-border transmission events. All multidrug-resistant isolates (33/104) belonged to Beijing sublineage 2.2.1.1 and had high-level isoniazid and ethionamide co-resistance; 2 isolates were extensively drug resistant. Including WGS in regional surveillance could improve tuberculosis transmission tracking and control strategies within the TSPZ.

References

Jul 3, 2004·The Journal of Biological Chemistry·Thomas BertrandKatherine A Brown
Oct 7, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Donna CowleyMark P Nicol
Oct 15, 2008·Systematic Biology·Alexandros StamatakisJacques Rougemont
Nov 13, 2009·Proceedings of the National Academy of Sciences of the United States of America·M Analise ZaunbrecherJames E Posey
Mar 1, 2012·Molecular Biology and Evolution·Alexei J DrummondAndrew Rambaut
Aug 7, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Chongguang YangQian Gao
Nov 20, 2012·The Lancet Infectious Diseases·Timothy M WalkerTim E A Peto
Feb 6, 2013·Antimicrobial Agents and Chemotherapy·Analise Z ReevesJames E Posey
Jan 28, 2014·Nature Genetics·Nicola CasaliFrancis Drobniewski
Apr 4, 2014·Bioinformatics·Anthony M BolgerBjoern Usadel
Mar 31, 2015·Lancet·Mukund UplekarUNKNOWN for WHO's Global TB Programme
May 12, 2015·Nature Communications·Vegard EldholmFrancois Balloux
Jul 19, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Ulziijargal GurjavVitali Sintchenko
Oct 16, 2015·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·Y Zhang, W-W Yew
Mar 28, 2016·The Lancet. Respiratory Medicine·Jennifer Furin, Helen Cox
Feb 23, 2017·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·E J DonnanC Nourse
May 10, 2017·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·K LönnrothC Lange

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Citations

Sep 11, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Qi JiangQian Gao
Feb 25, 2020·Emerging Infectious Diseases·Chuan-Chin HuangMegan B Murray

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Datasets Mentioned

BETA
PRJEB7281

Methods Mentioned

BETA
genotyping

Software Mentioned

MEM
SnpEff
FigTree
RAxML
GATK UnifiedGenotyper
BEAST
BWA
Sequence Read Archive
trimmomatic
R package

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