PMID: 6971661Jan 1, 1980Paper

Cross bridge slippage in skinned frog muscle fibres

Biophysics of Structure and Mechanism
Peter John GriffithsJ C Rüegg

Abstract

Mechanically skinned single fibres of the semitendinosus muscles of Rana esculenta were investigated at ca. 4 degrees C. The fibres were activated by a Ca2+ jump technique, which allowed the development of a steady isometric tension within several seconds of entering a calcium rich solution at 4 degrees C. Sequences of length changes of different duration and amplitude were applied to the fibre. It could be demonstrated that the fibre behaved as a Hookean spring in the case of small amplitude length changes (up to 0.5% L0, ramp duration 0.5 ms) and that a sequence of length changes induced reversible changes in fibre state. In contrast, large stretches (greater than 1% L0) induced a muscle "give" if the stretch were not immediately preceded by a release. The data was interpreted on the basis of a strain induced detachment of cross bridges in combination with a rapid reattachment of presumably the same cross bridges in a discharged position. The rates of strain induced detachment and reattachment depended on the stretch amplitude. At amplitudes exceeding 2% L0 the rates were estimated to be at least several thousands per second.

References

Jan 31, 1978·Pflügers Archiv : European journal of physiology·T Yamamoto, J W Herzig
Mar 1, 1978·The Journal of Physiology·F W Flitney, D G Hirst
Aug 1, 1979·The Journal of Physiology·F J Julian, D L Morgan
Nov 1, 1979·Pflügers Archiv : European journal of physiology·P J GriffithsJ C Rüegg
Dec 27, 1977·Biophysics of Structure and Mechanism·P Mason
Jul 12, 1978·Biophysics of Structure and Mechanism·K Güth, H J Kuhn
Sep 15, 1978·Experientia·K GüthJ C Rüegg
Jun 20, 1969·Science·H E Huxley
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Citations

Jun 1, 1983·Pflügers Archiv : European journal of physiology·G J StienenJ C Rüegg
Jul 29, 2008·Proceedings of the National Academy of Sciences of the United States of America·T I BekyarovaM K Reedy
Mar 31, 2009·International Journal of Molecular Sciences·Robert Jarosch
Nov 25, 1998·Biophysical Journal·E B GetzS L Lehman
Dec 1, 1992·Journal of Muscle Research and Cell Motility·K Burton
Nov 11, 2019·The Journal of Experimental Biology·Kaleena JohnstonWalter Herzog
May 8, 2019·Journal of Biomechanics·Atsuki FukutaniWalter Herzog

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