Cross-Coupling Hydrogen Evolution by Visible Light Photocatalysis Toward C(sp(2))-P Formation: Metal-Free C-H Functionalization of Thiazole Derivatives with Diarylphosphine Oxides

Organic Letters
Kai LuoLei Wu

Abstract

Visible light along with 5 mol % eosin B catalyzed the first direct C-H phosphorylation of thiazole derivatives with diarylphosphine oxides by a photoredox process in the absence of an external oxidant. The scope of thiazoles and phosphine oxides was further investigated, as was functional group tolerance. The general and operational simplicity provides a novel metal and oxidant-free alternative for the formation of heteroaryl-P bonds, and only molecular hydrogen is generated as a byproduct.

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Citations

Jun 7, 2017·Chemical Communications : Chem Comm·Zheng-Guang WuYi Pan
Nov 11, 2017·Organic & Biomolecular Chemistry·Qingrui LiYangjie Wu
Jun 4, 2019·Organic & Biomolecular Chemistry·Qiumin KeXiangmei Wu

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