PMID: 7858312Nov 1, 1994Paper

Cross-flow membrane plasmapheresis technique for continuous ex vivo plasma sampling

Journal of Pharmacological and Toxicological Methods
P M BungayC S Patlak


A technique is described for plasma sampling by continuous membrane plasmapheresis performed on blood flowing through an extracorporeal arteriovenous shunt. The plasmapheresis sampler in the shunt employs replaceable commercial planar membranes 2.5 cm in diameter. Validation tests were conducted for 0.6-micron pore diameter microporous membranes with several low-molecular-weight, nonmetabolized solutes that either rapidly equilibrate between plasma and formed elements or remain extracellular. Ex vivo tests were performed for bolus intravenous administration to rabbits. The technique yielded values for time-averaged plasma concentrations comparable to those obtained with serial blood and continuous blood withdrawal methods. The new technique should be particularly advantageous when the distribution of the solute of interest between plasma and formed elements of the blood undergoes significant changes during the sampling interval as a result of binding, exchange, or metabolism in the formed element phase.


Dec 2, 1977·European Journal of Clinical Pharmacology·B Beermann, M Groschinsky-Grind
Jun 1, 1978·Journal of Pharmaceutical Sciences·C R Kowarski, A A Kowarski
Dec 1, 1982·Journal of Pharmaceutical Sciences·J D Huang, S Oie
Nov 1, 1994·Journal of Pharmacological and Toxicological Methods·P M BungayP Krindel


Nov 1, 1994·Journal of Pharmacological and Toxicological Methods·P M BungayP Krindel

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