Cross-generalization of an EtOH "hangover" cue to endogenously and exogenously induced stimuli

Pharmacology, Biochemistry, and Behavior
D.V. GauvinF A Holloway

Abstract

Twenty male Sprague-Dawley rats were trained in a two-choice food-reinforced drug discrimination task (10 min sessions) using the state-dependent interoceptive stimulus attributes of ethanol's (EtOH) delayed or rebound effects (EDE) versus "normal" basal homeostasis. Cross-generalization tests were conducted with 0.18 mg/kg naloxone injected after three days of three injections per day of either SAL or 10 mg/kg morphine. Naloxone failed to generalize to the EDE-state after chronic saline; however, the precipitated morphine withdrawal state produced complete generalization to the EDE training cue. Daily tests were conducted after 8 h photoperiod phase-shifts. An 8 h phase-advance, equivalent to a west-to-east intercontinental night-time flight in humans, produced a biphasic, graded, increase in EDE-appropriate responding, which peaked on the second day after the phase-advance and recovered by the fourth day. The 8 h phase-delays failed to engender significant EDE-appropriate responding. These data provide evidence for the subjective similarity between EtOH hangover, opiate withdrawal states, and the physiological disruption induced by circadian phase-advances.

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Citations

Oct 13, 1998·Pharmacology, Biochemistry, and Behavior·T J BairdD V Gauvin
Oct 9, 1999·Pharmacology, Biochemistry, and Behavior·D V Gauvin, T J Baird
Jan 8, 1999·Peptides·G A OlsonA J Kastin
Apr 11, 2014·Behavioural Brain Research·Analía G KaradayianRodolfo A Cutrera
Aug 28, 2012·Pharmacology, Biochemistry, and Behavior·Laura RicheyTerrence Deak
Dec 19, 2017·Birth Defects Research·Cheril Tapia-RojasRodrigo A Quintanilla
Jul 12, 2021·Pharmacology, Biochemistry, and Behavior·Paige MarslandTerrence Deak

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