Cross-Immunity and Community Structure of a Multiple-Strain Pathogen in the Tick Vector

Applied and Environmental Microbiology
Jonas DurandMaarten J Voordouw

Abstract

Many vector-borne pathogens consist of multiple strains that circulate in both the vertebrate host and the arthropod vector. Characterization of the community of pathogen strains in the arthropod vector is therefore important for understanding the epidemiology of mixed vector-borne infections. Borrelia afzelii and B. garinii are two species of tick-borne bacteria that cause Lyme disease in humans. These two sympatric pathogens use the same tick, Ixodes ricinus, but are adapted to different classes of vertebrate hosts. Both Borrelia species consist of multiple strains that are classified using the highly polymorphic ospC gene. Vertebrate cross-immunity against the OspC antigen is predicted to structure the community of multiple-strain Borrelia pathogens. Borrelia isolates were cultured from field-collected I. ricinus ticks over a period spanning 11 years. The Borrelia species of each isolate was identified using a reverse line blot (RLB) assay. Deep sequencing was used to characterize the ospC communities of 190 B. afzelii isolates and 193 B. garinii isolates. Infections with multiple ospC strains were common in ticks, but vertebrate cross-immunity did not influence the strain structure in the tick vector. The pattern of genetic...Continue Reading

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Citations

Sep 20, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Maxime JacquetMaarten J Voordouw
Sep 29, 2015·Environmental Microbiology·Maxime JacquetMaarten J Voordouw
Jan 6, 2017·Scientific Reports·Dieter J A HeylenMaarten J Voordouw
Nov 12, 2016·Applied and Environmental Microbiology·Jonas DurandMaarten J Voordouw
Nov 2, 2018·Proceedings. Biological Sciences·Dolores GennéMaarten J Voordouw
Sep 22, 2019·Applied and Environmental Microbiology·Andrea Gomez-ChamorroMaarten J Voordouw
May 2, 2019·Scientific Reports·Andrea Gomez-ChamorroMaarten Jeroen Voordouw
Jun 28, 2018·The ISME Journal·Benjamin D RossJoseph D Mougous
Jan 11, 2020·Frontiers in Cellular and Infection Microbiology·Dolores GennéMaarten J Voordouw
Jul 12, 2017·Scientific Reports·Alessandro BelliMaarten J Voordouw
Mar 3, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Mehrnaz NouriLars Råberg
Mar 22, 2021·Parasites & Vectors·Cindy BregnardMaarten Jeroen Voordouw

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