Cross immunity of DNA vaccine pVAX1-cSZ2-IL-2 to Eimeria tenella, E. necatrix and E. maxima

Experimental Parasitology
Mohammed Ali A ShahXiangrui Li

Abstract

The study describes cross protection experiments with chimeric DNA vaccine pVAX1-cSZ2-IL-2 to determine its efficacy against four important Eimeria species. Seven-day-old chickens were randomly divided into nine groups; group 1 negative control, groups 2, 3, 4, 5 positive controls; and groups 6, 7, 8 and 9 experimental groups. On days 7 and 14, groups 1-5 were injected with TE buffer, and groups 6-9 with the vaccine. At 21 days of age, all chickens were inoculated with 5 x 10(4) sporulated oocysts except for the negative control. Groups 2 and 6 were inoculated with Eimeria tenella, groups 3 and 7 with Eimerianecatrix, groups 4 and 8 with Eimeria acervulina and groups 5 and 9 with Eimeria maxima. Seven days later, all chickens were weighed and slaughtered to obtain intestinal samples. Efficacy of immunization was evaluated on the basis of oocyst decrease ratio, lesion score, body-weight gain and anti-coccidial index. The results indicated that the recombinant plasmid can induce host immune responses by alleviating intestinal lesions, body weight loss and oocyst ratio and imparting good protection against E. tenella and E.acervulina, medium protection against E. necatrix but little effect against E. maxima. It is concluded that t...Continue Reading

References

Oct 25, 2002·Avian Pathology : Journal of the W.V.P.A·R B Williams
May 10, 2005·Experimental Parasitology·Alireza Talebi, Grace Mulcahy
Jun 7, 2005·Experimental Parasitology·Christian KlotzThomas Pogonka

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Citations

Jun 25, 2010·Parasitology Research·Muhammad Ali A ShahXiangrui Li
Jan 23, 2016·Veterinary Parasitology·ZhenChao ZhangXiangRui Li
May 28, 2013·The Korean Journal of Parasitology·Jinjun XuJianping Tao

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