PMID: 9551183Jan 1, 1997Paper

Cross-interactions between two members of the Dlx family of homeobox-containing genes during zebrafish development

Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire
T ZeruchaMarc Ekker

Abstract

The Dlx homeobox genes of vertebrates are transcribed in multiple cells of the embryo with overlapping patterns but often with different onsets of expression. Here we describe the interaction between two dlx genes, dlx3 and dlx4, during zebrafish development. The observation that dlx3 expression precedes that of dlx4 in the otic vesicle led us to investigate whether dlx3 had the ability to control expression of dlx4. Truncated versions of dlx3 were overexpressed in zebrafish embryos and the expression patterns of dlx4 were examined later in development. Overexpression of truncated forms of Dlx3 or of a Dlx3-Dlx2 chimera was found to result in perturbations in dlx4 expression. In addition, cotransfection experiments indicated the ability of Dlx3 to activate transcription through a 1.7-kb fragment of the 5' flanking region of dlx4. These results suggest that dlx4 is one of the target genes of dlx3 in embryos and that cross-regulatory interactions between Dlx genes may be one of the mechanisms responsible for their overlapping expression.

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Citations

Mar 15, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·L VerreijdtA Huysseune
Sep 7, 2012·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Kenta SumiyamaChris T Amemiya
Aug 23, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·Pamela C Yelick, Thomas F Schilling
Oct 12, 1999·The Journal of Comparative Neurology·D D EisenstatJ L Rubenstein
Jan 6, 2001·The Journal of Experimental Zoology·J Capdevila, J C Izpisúa Belmonte
Dec 5, 2000·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·T Zerucha, M Ekker
Jul 25, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M J Beanan, T D Sargent

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