Cross-kingdom inhibition of breast cancer growth by plant miR159

Cell Research
Andrew R ChinShizhen Emily Wang

Abstract

MicroRNAs (miRNAs) are critical regulators of gene expression, and exert extensive impacts on development, physiology, and disease of eukaryotes. A high degree of parallelism is found in the molecular basis of miRNA biogenesis and action in plants and animals. Recent studies interestingly suggest a potential cross-kingdom action of plant-derived miRNAs, through dietary intake, in regulating mammalian gene expression. Although the source and scope of plant miRNAs detected in mammalian specimens remain controversial, these initial studies inspired us to determine whether plant miRNAs can be detected in Western human sera and whether these plant miRNAs are able to influence gene expression and cellular processes related to human diseases such as cancer. Here we found that Western donor sera contained the plant miRNA miR159, whose abundance in the serum was inversely correlated with breast cancer incidence and progression in patients. In human sera, miR159 was predominantly detected in the extracellular vesicles, and was resistant to sodium periodate oxidation suggesting the plant-originated 2'-O-methylation on the 3' terminal ribose. In breast cancer cells but not non-cancerous mammary epithelial cells, a synthetic mimic of miR159...Continue Reading

References

Apr 3, 1992·Cell·G I EvanD C Hancock
Jun 23, 1999·Oncogene·G C Prendergast
Apr 18, 2003·Current Biology : CB·Michael T VeemanRandall T Moon
Feb 12, 2005·Science·Bin YuXuemei Chen
Jul 12, 2005·Oncogene·Nicole L MartinGuy Sauvageau
Aug 17, 2005·Cancer Research·Marilena V IorioCarlo M Croce
Oct 25, 2006·Nature Reviews. Cancer·George A Calin, Carlo M Croce
Dec 5, 2006·Oncogene·L ArceM L Waterman
Sep 25, 2007·Methods : a Companion to Methods in Enzymology·Ulf Andersson Orom, Anders H Lund
Oct 6, 2007·Proceedings of the National Academy of Sciences of the United States of America·Robert S AllenAnthony A Millar
Oct 19, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shannon Reagan-ShawNihal Ahmad
Jul 1, 2008·Gynecologic Oncology·Douglas D Taylor, Cicek Gercel-Taylor
Jul 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Patrick S MitchellMuneesh Tewari
May 21, 2009·BMC Research Notes·Weizhu ZhuEdward R Sauter
Jul 7, 2009·Annual Review of Cell and Developmental Biology·Xuemei Chen
Jul 10, 2010·Nucleic Acids Research·Kai WangDavid J Galas
Mar 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jason D ArroyoMuneesh Tewari
Jun 3, 2011·The Journal of Clinical Investigation·Brian D LehmannJennifer A Pietenpol
Mar 3, 2012·Medicinal Research Reviews·Ke Zen, Chen-Yu Zhang
Mar 16, 2012·Current Opinion in Lipidology·Kasey C Vickers, Alan T Remaley
May 15, 2012·Current Opinion in Genetics & Development·Xuemei Chen
Aug 10, 2012·BMC Genomics·Yuanji ZhangGreg Heck
Aug 21, 2012·Pharmacology & Therapeutics·Roxana S RedisGeorge A Calin
Nov 28, 2012·Proceedings of the National Academy of Sciences of the United States of America·Xiaolu A CambronneRichard H Goodman
May 15, 2013·RNA Biology·Jonathan W SnowStephen Y Chan
Nov 12, 2013·Nature Biotechnology·Brent DickinsonWilliam S Marshall
Apr 17, 2014·Cancer Cell·Weiying ZhouShizhen Emily Wang
Dec 5, 2014·Food Science & Nutrition·GaoFeng LiangZhongDang Xiao
Feb 24, 2015·The Journal of Nutritional Biochemistry·Hongwei LiangChen-Yu Zhang

❮ Previous
Next ❯

Citations

Jul 19, 2016·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Stefano PirròCarla Montesano
Sep 9, 2016·Scientific Reports·Chiara PastrelloIgor Jurisica
Oct 30, 2016·RNA Biology·Kenneth W Witwer, Marc K Halushka
Nov 20, 2016·Journal of the Science of Food and Agriculture·Ying-Hui HouChao-Ling Wei
Dec 28, 2016·International Journal of Molecular Sciences·Anna Lukasik, Piotr Zielenkiewicz
Apr 22, 2017·RNA Biology·Waqar IslamLiande Wang
Apr 6, 2017·Science China. Life Sciences·Jianchao DuChengyu Jiang
Apr 5, 2018·Science China. Life Sciences·Wen ZhangZhen Zhou
Apr 17, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wenyan Xie, Matthias F Melzig
Feb 25, 2018·Applied Biochemistry and Biotechnology·Swati SrivastavaAshok Sharma
Sep 1, 2017·PLoS Genetics·Kegan ZhuXi Chen
Nov 27, 2018·RNA Biology· SanchitaPrabodh Kumar Trivedi
Feb 1, 2018·BMC Complementary and Alternative Medicine·Xuan ChenGuan-Hai Dai
Oct 5, 2018·Annual Review of Animal Biosciences·Janos ZempleniEzra Mutai
May 24, 2019·Advances in Nutrition·Lin ZhangYong-Liang Zhang
Jun 6, 2019·American Journal of Physiology. Cell Physiology·Meng LiYong-Liang Zhang
Jun 25, 2019·Database : the Journal of Biological Databases and Curation·Dongliang YuYijun Meng
Feb 28, 2020·Cells·Clodagh P O'Neill, Róisín M Dwyer
Dec 5, 2019·Advances in Nutrition·Javaria MunirSeongho Ryu
Aug 28, 2019·Communications Biology·Katia AquilanoDaniele Lettieri-Barbato
Aug 31, 2020·Advances in Nutrition·Abdul Fatah A SamadMuhammad Sajad
Sep 24, 2020·Annual Review of Nutrition·Elizabeth M McNeill, Kendal D Hirschi
Mar 21, 2017·Molecular Nutrition & Food Research·Jian YangKendal D Hirschi
Apr 7, 2017·Scientific Reports·Yi LuoMingzhou Li
Jun 8, 2017·International Journal of Molecular Sciences·Dinesh KumarJayashankar Das
Jul 12, 2017·Genes & Nutrition·Kendal D Hirschi
Mar 9, 2018·Frontiers in Microbiology·Qingqing FengYan-Dong Wang
Mar 7, 2018·Genes & Nutrition·Jian YangKendal D Hirschi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.