Cross-Linked Fluorescent Supramolecular Nanoparticles for Intradermal Controlled Release of Antifungal Drug-A Therapeutic Approach for Onychomycosis

ACS Nano
Fang WangHsian-Rong Tseng

Abstract

The existing approaches to onychomycosis demonstrate limited success since the commonly used oral administration and topical cream only achieve temporary effective drug concentration at the fungal infection sites. An ideal therapeutic approach for onychomycosis should have (i) the ability to introduce antifungal drugs directly to the infected sites; (ii) finite intradermal sustainable release to maintain effective drug levels over prolonged time; (iii) a reporter system for monitoring maintenance of drug level; and (iv) minimum level of inflammatory responses at or around the fungal infection sites. To meet these expectations, we introduced ketoconazole-encapsulated cross-linked fluorescent supramolecular nanoparticles (KTZ⊂c-FSMNPs) as an intradermal controlled release solution for treating onychomycosis. A two-step synthetic approach was adopted to prepare a variety of KTZ⊂c-FSMNPs. Initial characterization revealed that 4800 nm KTZ⊂c-FSMNPs exhibited high KTZ encapsulation efficiency/capacity, optimal fluorescent property, and sustained KTZ release profile. Subsequently, 4800 nm KTZ⊂c-FSMNPs were chosen for in vivo studies using a mouse model, wherein the KTZ⊂c-FSMNPs were deposited intradermally via tattoo. The results obta...Continue Reading

References

Oct 23, 2003·Dermatology : International Journal for Clinical and Investigative Dermatology·Jorge E Arrese, Gérald E Piérard
Nov 13, 2004·Dermatology : International Journal for Clinical and Investigative Dermatology·Jean-Claude RoujeauCarle Paul
May 9, 2009·Angewandte Chemie·Hao WangHsian-Rong Tseng
Mar 4, 2010·Chemical Communications : Chem Comm·Hao WangHsian-Rong Tseng
Sep 14, 2010·Journal of Clinical Pharmacy and Therapeutics·J ThomasC Sharpe
Aug 9, 2011·Journal of the American Academy of Dermatology·Aditya K GuptaAntonella Tosti
Nov 15, 2011·Biomaterials·Kuan-Ju ChenHsian-Rong Tseng
Jul 17, 2013·Journal of the American Academy of Dermatology·Caitlin CarneyBoni Elewski
Nov 29, 2013·Journal of the European Academy of Dermatology and Venereology : JEADV·B Sigurgeirsson, R Baran
Jun 26, 2014·Journal of Drug Targeting·Manish V SanerChandrakantsing V Pardeshi
Sep 27, 2014·American Journal of Clinical Dermatology·Aditya K GuptaKelly A Foley
Oct 2, 2014·Critical Reviews in Therapeutic Drug Carrier Systems·Bhavesh S BarotPragna K Shelat
Dec 20, 2014·Expert Opinion on Pharmacotherapy·Aditya K Gupta, Fiona C Simpson
May 23, 2015·Drug Development and Industrial Pharmacy·Avadhesh KushwahaHoward I Maibach
Jun 24, 2015·Proceedings of the National Academy of Sciences of the United States of America·Jicheng YuZhen Gu
Jan 15, 2016·Expert Opinion on Investigational Drugs·Aditya K Gupta, Catherine Studholme
Feb 15, 2016·Journal of the American Academy of Dermatology·Anil Kumar BhattaJing Jun Zhao
Mar 13, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·W J McAuleyM B Brown
Feb 22, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Guojun Ma, Chengwei Wu
Apr 5, 2017·American Journal of Clinical Dermatology·Ana Luiza LimaPeter Elsner
May 28, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shubhmita BhatnagarVenkata Vamsi Krishna Venuganti
Jun 4, 2017·Materials Science & Engineering. C, Materials for Biological Applications·Peizong DengRunliang Feng
Feb 3, 2018·Journal of the American Society for Mass Spectrometry·Li-En LinCheng-Chih Hsu

❮ Previous
Next ❯

Citations

May 17, 2019·Pharmaceutical Nanotechnology·Rupinder K DhamoonMadhu Gupta
Apr 8, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiangyu SunLaiqiang Huang
Dec 18, 2019·International Journal of Pharmaceutics·Sai LuJinliang Peng
Apr 22, 2020·Analytical Chemistry·Penghsuan HuangPi-Tai Chou
Aug 27, 2021·Advanced Drug Delivery Reviews·Benjamin A KuzmaConor L Evans

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.