Cross-linking of a biopolymer-peptide co-assembling system

Acta Biomaterialia
Karla E Inostroza-BritoAlvaro Mata

Abstract

The ability to guide molecular self-assembly at the nanoscale into complex macroscopic structures could enable the development of functional synthetic materials that exhibit properties of natural tissues such as hierarchy, adaptability, and self-healing. However, the stability and structural integrity of these kinds of materials remains a challenge for many practical applications. We have recently developed a dynamic biopolymer-peptide co-assembly system with the capacity to grow and undergo morphogenesis into complex shapes. Here we explored the potential of different synthetic (succinimidyl carboxymethyl ester, poly (ethylene glycol) ether tetrasuccinimidyl glutarate and glutaraldehyde) and natural (genipin) cross-linking agents to stabilize membranes made from these biopolymer-peptide co-assemblies. We investigated the cross-linking efficiency, resistance to enzymatic degradation, and mechanical properties of the different cross-linked membranes. We also compared their biocompatibility by assessing the metabolic activity and morphology of adipose-derived stem cells (ADSC) cultured on the different membranes. While all cross-linkers successfully stabilized the system under physiological conditions, membranes cross-linked with...Continue Reading

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Citations

Nov 8, 2019·Biomaterials Science·Nitin YadavVirander S Chauhan
Jun 22, 2019·Nature Reviews. Materials·Lorenzo MoroniJames J Yoo
Jul 10, 2019·Matrix Biology : Journal of the International Society for Matrix Biology·Arturo Ibáñez-FonsecaJosé Carlos Rodríguez-Cabello
Oct 7, 2021·Macromolecular Bioscience·Jagan Mohan DoddaRotimi Sadiku
Dec 24, 2021·ACS Applied Materials & Interfaces·Moumita GhoshLihi Adler-Abramovich

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