PMID: 2425339Jun 25, 1986

Cross-linking of initiation factor IF3 to Escherichia coli 30S ribosomal subunit by trans-diamminedichloroplatinum(II): characterization of two cross-linking sites in 16S rRNA; a possible way of functioning for IF3

Nucleic Acids Research
C EhresmannB Ehresmann


The initiation factor IF3 is platinated with trans-diamminedichloroplatinum(II) and cross-linked to Escherichia coli 30S ribosomal subunit. Two cross-linking sites are unambiguously identified on the 16S rRNA: a major one, in the region 819-859 in the central domain, and a minor one, in the region 1506-1529 in the 3'-terminal domain. Specific features of these sequences together with their particular location within the 30S subunit lead us to postulate a role for IF3, that conciliates topographical and functional observations made so far.


Apr 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·S M Politz, D G Glitz
Jul 15, 1977·FEBS Letters·D Brauer, B Wittmann-Liebold
Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H M Olson, D G Glitz
Feb 24, 1976·Biochemistry·C L Pon, C O Gualerzi
Feb 15, 1976·FEBS Letters·J van DuinJ P Ebel
Nov 15, 1975·FEBS Letters·J van DuinM Grunberg-Manago
Aug 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·A E Dahlberg, J E Dahlberg
Oct 15, 1975·FEBS Letters·A P CzernilofskyG Stöffler
Jul 5, 1985·Journal of Molecular Biology·A Expert-Bezançon, P Wollenzien
Jan 1, 1972·Molecular & General Genetics : MGG·C L PonC O Gualerzi
Nov 27, 1974·Biochemical and Biophysical Research Communications·D A HawleyA J Wahba
Apr 16, 1973·Biochemical and Biophysical Research Communications·R A Kenner
Mar 1, 1980·Archives of Biochemistry and Biophysics·E WickstromE E Williams


Apr 28, 1995·Journal of Molecular Biology·D MoazedH F Noller
Jun 8, 2011·Proceedings of the National Academy of Sciences of the United States of America·Chao TuXinhua Ji
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J S ButlerM Grunberg-Manago
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·W E TapprichA E Dahlberg
Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·J P McCutcheonJ Frank
Nov 20, 1988·Journal of Molecular Biology·S SternH F Noller
Dec 17, 2011·Biochimica Et Biophysica Acta·Brooke E Christian, Linda L Spremulli
Jul 10, 1998·Structure·J P Rife, P B Moore
Apr 8, 2006·Molecular Cell·Sean M Studer, Simpson Joseph
Oct 3, 2002·Biochemical and Biophysical Research Communications·Isabella Moll, U Bläsi
May 24, 2003·Cold Spring Harbor Symposia on Quantitative Biology·A BashanA Yonath
Jun 26, 1990·Biochemistry·C O Gualerzi, C L Pon
Feb 7, 1997·The Journal of Biological Chemistry·Y MelanderO Nygârd

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Cross-Linking Reagents
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