Cross-modal plasticity among sensory networks in neuromyelitis optica spectrum disorders

Multiple Sclerosis : Clinical and Laboratory Research
Maria A RoccaMassimo Filippi

Abstract

To explore resting-state (RS) functional connectivity (FC) of the main sensory/motor networks of patients with neuromyelitis optica spectrum disorders (NMOSDs), clinically isolated optic neuritis (ON), and myelitis. Clinical evaluation and RS fMRI were obtained from 28 NMOSD, 11 recurrent ON, and 12 recurrent myelitis patients and 30 healthy controls. Between-group RS FC comparisons and correlations with motor performance were assessed (SPM12) on the main sensory/motor RS networks (RSNs) identified by independent component analysis. Functional network connectivity analysis estimated inter-network connectivity. Intra- and inter-network RS FCs were reduced in RSNs associated to somatosensory modalities affected by pathology: regions of the primary visual network in ON patients, of the sensorimotor networks in myelitis patients, and of the sensorimotor and secondary visual networks in NMOSD patients. The opposite trend was observed in regions of RSNs spared by pathology: the auditory and part of visual networks in NMOSD, the secondary visual and sensorimotor networks in ON, and the primary visual network in myelitis patients. Better motor performance correlated with higher RS FC of spared RSNs. Sensory and motor RSN abnormalities ...Continue Reading

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Citations

May 14, 2019·Multiple Sclerosis : Clinical and Laboratory Research·Filippo SavoldiMassimo Filippi
Mar 4, 2020·Neurology. Neuroimmunology and Neuroinflammation·Yael BacknerNetta Levin
Apr 6, 2021·Brain Connectivity·Milagros Hidalgo de la CruzMassimo Filippi

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Methods Mentioned

BETA
imaging techniques

Software Mentioned

FNC
ICASSO
SPM12
GIFT
SPSS

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