Cross-presentation, dendritic cell subsets, and the generation of immunity to cellular antigens

Immunological Reviews
William R HeathJose A Villadangos

Abstract

Cross-presentation involves the uptake and processing of exogenous antigens within the major histocompatibility complex (MHC) class I pathway. This process is primarily performed by dendritic cells (DCs), which are not a single cell type but may be divided into several distinct subsets. Those expressing CD8alpha together with CD205, found primarily in the T-cell areas of the spleen and lymph nodes, are the major subset responsible for cross-presenting cellular antigens. This ability is likely to be important for the generation of cytotoxic T-cell immunity to a variety of antigens, particularly those associated with viral infection, tumorigenesis, and DNA vaccination. At present, it is unclear whether the CD8alpha-expressing DC subset captures antigen directly from target cells or obtains it indirectly from intermediary DCs that traffic from peripheral sites. In this review, we examine the molecular basis for cross-presentation, discuss the role of DC subsets, and examine the contribution of this process to immunity, with some emphasis on DNA vaccination.

References

Nov 1, 1992·Immunology Today·E Fuchs
Feb 1, 1990·The Journal of Experimental Medicine·F R Carbone, M J Bevan
Oct 1, 1987·Nature·U D StaerzA M Garner
Jan 1, 1989·Cold Spring Harbor Symposia on Quantitative Biology·C A Janeway
Jun 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·M Kovacsovics-BankowskiK L Rock
Aug 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·B DoeC M Walker
Oct 1, 1996·Nature Medicine·C CondonL D Falo
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·K AhnK Früh
Oct 1, 1996·The Journal of Experimental Medicine·T De SmedtM Moser
Oct 1, 1996·The Journal of Experimental Medicine·M CorrH Tighe
Sep 1, 1996·The Journal of Experimental Medicine·C KurtsH Kosaka
Apr 1, 1997·Immunological Reviews·R M SteinmanK Inaba
Jul 7, 1997·The Journal of Experimental Medicine·S R BennettW R Heath
Nov 14, 1997·Proceedings of the National Academy of Sciences of the United States of America·J LevitskayaM G Masucci
Feb 26, 1998·Cell·K E MatlackT A Rapoport
May 2, 1998·Science·H L Ploegh
Jan 5, 1999·The Journal of Experimental Medicine·O AkbariB Stockinger
Feb 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·B PulendranC R Maliszewski
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·D J MorganL A Sherman
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·C KurtsW R Heath
Nov 5, 1999·Nature Medicine·S GallucciP Matzinger
Jan 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·K OhashiH Kolb
Jan 13, 2000·Immunological Reviews·P CresswellG Diedrich

❮ Previous
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Citations

Dec 14, 2004·Springer Seminars in Immunopathology·Pierre Guermonprez, Sebastian Amigorena
Jan 27, 2011·Cancer Metastasis Reviews·Riad Abès, Jean-Luc Teillaud
Aug 8, 2008·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Yuri V BobryshevReginald V N Lord
Nov 19, 2008·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Yuri V BobryshevReginald V N Lord
Dec 27, 2011·Frontiers of Medicine·Hongmei Xu, Xuetao Cao
Mar 16, 2005·Current Opinion in Immunology·Willem W Overwijk
Mar 4, 2005·Nature·William R Heath, Francis R Carbone
Mar 19, 2008·Immunology and Cell Biology·Frederick MassonGabrielle T Belz
Apr 24, 2008·Immunology and Cell Biology·Lois L Cavanagh, Wolfgang Weninger
Apr 17, 2008·Immunology and Cell Biology·Shalin H Naik
Feb 13, 2008·Immunology and Cell Biology·Ming-Lee LinAndrew M Lew
Sep 10, 2008·Immunology and Cell Biology·Anna I ProiettoLi Wu
Apr 22, 2009·Immunology and Cell Biology·Eugene MaraskovskyDebbie Drane
Apr 7, 2010·Immunology and Cell Biology·Nikolaus RomaniVincent Flacher
Jan 11, 2012·Immunology and Cell Biology·Sioh-Yang TanWolfgang Weninger
Jul 13, 2011·Immunology and Cell Biology·Sawang Petvises, Helen C O'Neill
Sep 7, 2011·Immunology and Cell Biology·Nicholas S WilsonEugene Maraskovsky
Mar 4, 2005·Nature·Joost NeijssenJacques Neefjes
Feb 16, 2005·Nature·Oliver SchulzCaetano Reis e Sousa
Mar 14, 2007·Nature Cell Biology·Carolina JancicSebastian Amigorena
Apr 8, 2009·Nature Immunology·Sammy BedouiWilliam R Heath
Dec 22, 2004·Nature Immunology·Loredana Saveanu, Peter van Endert
Jan 21, 2006·Nature Immunology·Marco ColonnaAkiko Iwasaki
Jan 21, 2006·Nature Immunology·Heather D Hickman-Miller, Jonathan W Yewdell
Apr 22, 2009·Nature Immunology·Akiko Iwasaki
May 24, 2005·Nature Immunology·Cornelis J M Melief
Oct 12, 2004·Nature Immunology·Christopher M SmithGabrielle T Belz
Jan 26, 2008·Nature Reviews. Cancer·Jason RiceFreda K Stevenson
Feb 3, 2005·Nature Reviews. Immunology·Mariapia A Degli-Esposti, Mark J Smyth
May 13, 2006·Nature Reviews. Immunology·Caetano Reis e Sousa
Dec 16, 2006·Nature Reviews. Immunology·Ken Shortman, Shalin H Naik
Jun 26, 2007·Nature Reviews. Immunology·José A Villadangos, Petra Schnorrer
Oct 20, 2007·Cell Death and Differentiation·M V DhodapkarA K Palucka
Jan 28, 2006·Cancer Gene Therapy·R G van der MostD J Nelson

❮ Previous
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