Cross-presentation: how to get there - or how to get the ER.

Frontiers in Immunology
Christoph KreerSven Burgdorf

Abstract

Antigen cross-presentation enables dendritic cells (DCs) to present extracellular antigens on major histocompatibility complex (MHC) I molecules, a process that plays an important role in the induction of immune responses against viruses and tumors and in the induction of peripheral tolerance. In order to allow intracellular processing for cross-presentation, internalized antigens are targeted by distinct endocytic receptors toward specific endosomal compartments, where they are protected from rapid lysosomal degradation. From these compartments, antigens are processed for loading onto MHC I molecules. Such processing generally includes antigen transport into the cytoplasm, a process that is regulated by members of the ER-associated degradation (ERAD) machinery. After proteasomal degradation in the cytoplasm, antigen-derived peptides have been shown to be re-imported into the same endosomal compartment by endosomal transporter associated with antigen processing, another ER protein, which is recruited toward the endosomes after DC maturation. In our review, we highlight the recent advances on the molecular mechanisms of cross-presentation. We focus on the necessity of such antigen storage compartments and point out important par...Continue Reading

Citations

Aug 1, 2012·Cellular and Molecular Life Sciences : CMLS·Kristi BakerRichard S Blumberg
Nov 11, 2019·BMC Health Services Research·Kelsey C Priest, Dennis McCarty
Jul 16, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jodie P GoodridgeDaniel E Geraghty
Mar 12, 2021·Advanced Functional Materials·Shannon J TsaiChristopher M Jewell

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