PMID: 11923104Mar 30, 2002Paper

Cross-priming versus cross-tolerance: are two signals enough?

Trends in Immunology
Thomas Blankenstein, Thomas Schüler

Abstract

Depending on their state of maturation, dendritic cells (DCs) can cross-prime or cross-tolerize T cells. Mature DCs provide T-cell-receptor ligands (signal 1) and costimulatory molecules (signal 2), and activate T cells. Immature DCs provide signal 1, but not signal 2, and tolerize T cells. However, new data show that it is not the expression of costimulatory molecules alone that determines whether DCs induce immunity or tolerance, because mature DCs can induce tolerance also.

References

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Citations

Jan 14, 2005·Cancer Immunology, Immunotherapy : CII·Thomas FelzmannWolfgang Holter
Mar 24, 2004·Seminars in Immunology·Hervé GrouxFrançoise Cottrez
Apr 23, 2003·Immunology Letters·Dominik Wodarz, Vincent A A Jansen
Aug 30, 2002·Trends in Immunology·Manfred B Lutz, Gerold Schuler
Sep 4, 2003·The Cancer Journal·Duane A MitchellJohn H Sampson
Mar 19, 2003·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Bao-Guo XiaoHans Link
Oct 6, 2012·Therapeutic Delivery·Kenneth C McCulloughNicolas Ruggli
May 20, 2003·Immunological Reviews·Elise ChiffoleauLaurence Turka
Sep 17, 2003·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Monika GadAnders Elm Pedersen
Jun 24, 2008·Transfusion Medicine Reviews·Bernard Khor, Robert S Makar
Dec 24, 2009·Cellular & Molecular Immunology·Yong Zhao, Xianchang Li
Mar 29, 2006·European Journal of Immunology·Benoit VingertEric Tartour
May 22, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Angela DolganiucGyongyi Szabo
Jul 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marina NikulinaHubert Kolb

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