PMID: 8972053Oct 1, 1996Paper

Cross-protection between Actinobacillus pleuropneumoniae biotypes-serotypes in pigs

Veterinary Microbiology
F HaesebroukR Ducatelle

Abstract

Four groups of hysterectomy-derived and colostrum-deprived pigs were intranasally inoculated with an Actinobacillus pleuropneumoniae biotype 1-serotype 2 strain (producing RTX toxins ApxII and ApxIII. 6 pigs), an A. pleuropneumoniae biotype 1-serotype 10 strain (producing ApxI. 5 pigs), an A. pleuropneumoniae biotype 2-serotype 2 strain (producing ApxII, 5 pigs) or saline (controls, 7 pigs). All pigs were exposed to A. pleuropneumoniae biotype 1-serotype 2 endobronchial challenge. After challenge, severe clinical signs were observed in all control pigs, one pig immunized with the A. pleuropneumoniae biotype 1-serotype 10 strain and two pigs immunized with the A. pleuropneumoniae biotype 2-serotype 2 strain. These pigs died within 36 h after challenge and 20 to 50% of the lungs were macroscopically affected. In the other pigs, clinical signs were mild or absent and no or only small, focal lung lesions were observed when euthanized at 48 h after challenge. At the time challenge neutralizing antibodies against ApxI only. ApxII only and both ApxII and III were present in sera of pigs immunized with the A. pleuropneumoniae biotype 1-serotype 10 strain, the A. pleuropneumoniae biotype 2-serotype 2 strain and the A. pleuropneumoniae b...Continue Reading

References

Jun 1, 1992·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·P Dom, F Haesebrouck
Feb 11, 1992·Nucleic Acids Research·B M LoyndsJ S Kroll
Jan 1, 1991·Research in Veterinary Science·S SerebrinP B Little
Feb 1, 1994·Veterinary Microbiology·R A JolieB J Thacker

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Citations

Mar 20, 2001·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·I Van OverbekeF Haesebrouck
Aug 26, 2006·Veterinary Microbiology·Fuzhou XuHanchun Yang
Jan 21, 2000·The Veterinary Journal·A N Rycroft, L H Garside
Sep 25, 2017·Genome Announcements·Byung-Sun ParkNakhyung Lee
Mar 19, 2008·Animal Health Research Reviews·Mahendrasingh RamjeetMario Jacques

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