Cross-protection between species of the Schistosoma haematobium group induced by vaccination with irradiated parasites

Parasite Immunology
S NavarreteA M Agnew

Abstract

Mice vaccinated with irradiated cercariae of Schistosoma haematobium, S. bovis and S. margrebowiei showed good levels of resistance (38-62%) against an homologous challenge, and varying degrees of resistance (19-46%), against challenges with closely related species. No protection against S. mansoni was induced by vaccination with any of these species. This restricted cross-protection reflects the close phylogenetic relationship between species of the S. haematobium group and indicates that immunologically important epitopes are conserved within this species complex.

References

Jan 1, 1979·Transactions of the Royal Society of Tropical Medicine and Hygiene·G WebbeJ R Shaw
Jan 1, 1978·The American Journal of Tropical Medicine and Hygiene·P MinardK D Murrell
Sep 1, 1978·The American Journal of Tropical Medicine and Hygiene·D A DeanK D Murrell
Aug 1, 1992·Molecular and Biochemical Parasitology·F TrotteinA Capron
Aug 1, 1986·Molecular and Biochemical Parasitology·T K WalkerA J Simpson
Jan 1, 1985·Transactions of the Royal Society of Tropical Medicine and Hygiene·N A MoloneyG Webbe
Jan 1, 1970·Journal of Helminthology·M G Taylor
Jan 1, 1980·Transactions of the Royal Society of Tropical Medicine and Hygiene·C A Wright, G C Ross
May 1, 1993·Parasite Immunology·A M AgnewM J Doenhoff
Jan 1, 1961·Transactions of the Royal Society of Tropical Medicine and Hygiene·R J PITCHFORD
Oct 1, 1990·Trends in Ecology & Evolution·C Combes

Citations

Mar 1, 1996·International Journal for Parasitology·M HopeD P McManus
Sep 1, 1996·Parasitology Today·A Read, M Viney
Oct 8, 1998·International Journal for Parasitology·V R SouthgateL A Tchuenté
Nov 27, 2002·Molecular Phylogenetics and Evolution·J A MorganE S Loker

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