Cross-protection induced by Japanese encephalitis vaccines against different genotypes of Dengue viruses in mice

Scientific Reports
Jieqiong LiJing An

Abstract

Dengue viruses (DENVs) and Japanese encephalitis virus (JEV) are closely related mosquito-borne flaviviruses that cause very high global disease burdens. Although cross-reactivity and cross-protection within flaviviruses have been demonstrated, the effect of JEV vaccination on susceptibility to DENV infection has not been well elucidated. In this study, we found that vaccination with the JEV inactivated vaccine (INV) and live attenuated vaccine (LAV) could induce cross-immune responses and cross-protection against DENV1-4 in mice. Despite the theoretical risk of immune enhancement, no increased mortality was observed in our mouse model. Additionally, low but consistently detectable cross-neutralizing antibodies against DENV2 and DENV3 were also observed in the sera of JEV vaccine-immunized human donors. The results suggested that both JEV-LAV and JEV-INV could elicit strong cross-immunity and protection against DENVs, indicating that inoculation with JEV vaccines may influence the distribution of DENVs in co-circulated areas and that the cross-protection induced by JEV vaccines against DENVs might provide important information in terms of DENV prevention.

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Citations

Aug 16, 2016·The Journal of Infectious Diseases·Anna B Kawiecki, Rebecca C Christofferson
Oct 21, 2016·BMC Infectious Diseases·Yuka SaitoTomohiko Takasaki
Mar 15, 2018·Frontiers in Public Health·Erum KhanMaureen T Long
Feb 8, 2018·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A VermaR Kumar
Oct 17, 2019·Frontiers in Immunology·Lorrany Dos Santos FrancoJaime Henrique Amorim
Feb 23, 2020·Medical Microbiology and Immunology·Xiaoen HeWei Zhao
Jun 6, 2017·Trends in Immunology·Noemia S LimaLydie Trautmann
Jul 9, 2021·Reviews in Medical Virology·Tiantian WuYi-Ping Li

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

ImmunoSpot image analyzer
SPSS

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