PMID: 6641723Oct 1, 1983

Cross-reacting opsonic antibodies to clinically important pneumococcal serotypes after pneumococcal vaccination

European Journal of Clinical Microbiology
J H BraconierH Odeberg

Abstract

Opsonic activity of serum to pneumococcal serotypes 6 B, 9 V and 19 A was measured in 16 patients before and after immunization with a pneumococcal vaccine. The capsular polysaccharides of these serotypes are not included among, but are antigenically related to the vaccine polysaccharides. Patients responding to immunization with a twofold increase in serum antibodies to vaccine polysaccharides 6 A, 19 F and 23 F were studied. Increased opsonic activity towards serotypes 6 B, 9 V and 19 A was found in 12, four and ten patients respectively. In ten of the patients antibodies to serotypes 6 B, 9 V and 19 A were measured by a staphylococcal protein-A binding assay. A twofold increase in antibodies was found in postvaccination samples from ten, three and seven patients respectively. These results indicate that humans responding to pneumococcal vaccination, may also develop opsonic antibodies to other clinically important pneumococcal serotypes. The degree of cross-immunization appears to vary between individuals and between different pneumococcal serotypes.

References

Jan 1, 1974·Scandinavian Journal of Immunology·G DorvalH Wigzell
May 1, 1973·The Journal of Pediatrics·J A Winkelstein
Jan 1, 1966·International Archives of Allergy and Applied Immunology·P J McConahey, F J Dixon
Jan 1, 1974·Scandinavian Journal of Immunology·M Harboe, I Fölling
Mar 1, 1981·Reviews of Infectious Diseases·C J LeeK T Lin

Related Concepts

Antibodies, Bacterial
Bacterial Vaccines
Cross Reactions
Opsonin
Serotyping
Staphylococcus aureus
Streptococcus pneumoniae
Vaccination
Pneumovax

Related Feeds

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.