PMID: 8955484Dec 1, 1996Paper

Cross-reactions in patch testing and photopatch testing with ketoprofen, thiaprophenic acid, and cinnamic aldehyde.

American Journal of Contact Dermatitis : Official Journal of the American Contact Dermatitis Society
P D PigattoM Picardo

Abstract

In the last 7 years, we have studied 123 patients with allergic reactions to topical arylpropionic anti-inflammatory drugs. We have investigated the rate of sensitization and the irritant potential of one of them, ketoprofen, and its cross-reactivity with such other derivatives as ibuproxam, ibuprofen, naproxen, fenoprofen, flurbiprofen, and thiaprofenic acid. Sensitization was single in most cases, and ketoprofen was the drug most often involved. The combination most frequently found was ketoprofen plus ibuproxam. The most frequent cross-reactions were to fragrance mix, especially cinnamic aldehyde and balsam of Peru, both contact and photocontact sensitizers. Because there is a ketonic group in the molecule of ketoprofen and cinnamic aldehyde and after conversion of thiaprofenic acid, this could be the trigger for this particular allergy and cross-reactivity.

References

Aug 1, 1990·Contact Dermatitis·A TostiF Bardazzi
Nov 1, 1990·Contact Dermatitis·N Mozzanica, P D Pigatto
Nov 1, 1989·Contact Dermatitis·R ValsecchiT Cainelli
Aug 1, 1986·Contact Dermatitis·S VeronesiM Melino
Nov 1, 1987·Contact Dermatitis·N MozzanicaP Pigatto
Feb 1, 1986·Contact Dermatitis·A C de GrootB A Jagtman
Feb 1, 1985·Contact Dermatitis·A Alomar
May 1, 1985·Contact Dermatitis·R Valsecchi, T Cainelli
May 1, 1983·Contact Dermatitis·G Angelini, G A Vena

❮ Previous
Next ❯

Citations

Jan 17, 2004·Journal of the American Academy of Dermatology·Monica HindsénMagnus Bruze
Mar 10, 2006·Contact Dermatitis·Monika HindsénMagnus Bruze
Aug 26, 2006·Contact Dermatitis·Pascal GirardinFrançois Aubin
May 13, 2006·Contact Dermatitis·Ruth L DiazCarmelo Aguirre
Sep 2, 2008·Contact Dermatitis·Paolo Daniele PigattoColombina Vincenzi
May 18, 2004·Photodermatology, Photoimmunology & Photomedicine·An Goossens
Nov 9, 2007·Contact Dermatitis·Rebeca GoirizAmaro García-Diez
Dec 21, 2002·Contact Dermatitis·Nancy ValenzuelaAgustin Alomar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.