Cross-reactive antibody response between SARS-CoV-2 and SARS-CoV infections.

BioRxiv : the Preprint Server for Biology
Huibin LvChris K P Mok

Abstract

The World Health Organization has recently declared the ongoing outbreak of COVID-19, which is caused by a novel coronavirus SARS-CoV-2, as pandemic. There is currently a lack of knowledge in the antibody response elicited from SARS-CoV-2 infection. One major immunological question is concerning the antigenic differences between SARS-CoV-2 and SARS-CoV. We address this question by using plasma from patients infected by SARS-CoV-2 or SARS-CoV, and plasma obtained from infected or immunized mice. Our results show that while cross-reactivity in antibody binding to the spike protein is common, cross-neutralization of the live viruses is rare, indicating the presence of non-neutralizing antibody response to conserved epitopes in the spike. Whether these non-neutralizing antibody responses will lead to antibody-dependent disease enhancement needs to be addressed in the future. Overall, this study not only addresses a fundamental question regarding the antigenicity differences between SARS-CoV-2 and SARS-CoV, but also has important implications in vaccine.

Citations

May 12, 2020·Frontiers in Immunology·Cheryl Yi-Pin LeeLisa F P Ng
Aug 25, 2020·Der Nephrologe·H RohnO Witzke
Jun 26, 2020·Frontiers in Immunology·Walter Fierz, Brigitte Walz
May 14, 2020·AAS Open Research·Francis Kobia, Jesse Gitaka
Apr 19, 2020·Journal of Virology·Austin NguyenReid F Thompson
Jan 24, 2021·Nature Communications·Yashavanth Shaan LakshmanappaSmita S Iyer
Nov 28, 2020·Frontiers in Cellular and Infection Microbiology·Khursheed Ul Islam, Jawed Iqbal
Jan 26, 2021·Frontiers in Immunology·Fataneh TavasolianRobert D Inman

Datasets Mentioned

BETA
ABF65836.1
QHD43416.1

Methods Mentioned

BETA
ELISA
size exclusion chromatography
enzyme-linked immunosorbent assay

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