Cross-reactive microbial peptides can modulate HIV-specific CD8+ T cell responses

PloS One
Christopher W PohlmeyerJoel N Blankson

Abstract

Heterologous immunity is an important aspect of the adaptive immune response. We hypothesized that this process could modulate the HIV-1-specific CD8+ T cell response, which has been shown to play an important role in HIV-1 immunity and control. We found that stimulation of peripheral blood mononuclear cells (PBMCs) from HIV-1-positive subjects with microbial peptides that were cross-reactive with immunodominant HIV-1 epitopes resulted in dramatic expansion of HIV-1-specific CD8+ T cells. Interestingly, the TCR repertoire of HIV-1-specific CD8+ T cells generated by ex vivo stimulation of PBMCs using HIV-1 peptide was different from that of cells stimulated with cross-reactive microbial peptides in some HIV-1-positive subjects. Despite these differences, CD8+ T cells stimulated with either HIV-1 or cross-reactive peptides effectively suppressed HIV-1 replication in autologous CD4+ T cells. These data suggest that exposure to cross-reactive microbial antigens can modulate HIV-1-specific immunity.

References

Oct 7, 2003·Journal of Translational Medicine·Paula M AciernoSebastiano Gattoni-Celli
May 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Emma L TurnbullPersephone Borrow
Apr 13, 2007·Proceedings of the National Academy of Sciences of the United States of America·Asier Sáez-CiriónUNKNOWN Agence Nationale de Recherches sur le Sida EP36 HIV Controllers Study Group
Sep 22, 2010·AIDS Research and Human Retroviruses·Karen A O'ConnellJoel N Blankson
Jun 25, 2014·The Journal of Experimental Medicine·Suzanne L CampionFederica Sallusto
Apr 23, 2015·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Angela G HückelhovenThomas Harrer

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Datasets Mentioned

BETA
EFK55173.1
ADK79875.1
AFJ04417.1

Methods Mentioned

BETA
flow cytometry

Software Mentioned

pBLAST
Excel
ImmunoSeq
FlowJo
TreeStar

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