Cross-reactive recognition of human and primate cytomegalovirus sequences by human CD4 cytotoxic T lymphocytes specific for glycoprotein B and H

European Journal of Immunology
Rebecca ElkingtonRajiv Khanna

Abstract

Although the importance of CD4+ T cell responses to human cytomegalovirus (HCMV) has recently been recognized in transplant and immunosuppressed patients, the precise specificity and nature of this response has remained largely unresolved. In the present study we have isolated CD4+ CTL which recognize epitopes from HCMV glycoproteins gB and gH in association with two different HLA-DR antigens, DRA1*0101/DRB1*0701 (DR7) and DRA1*0101/DRB1*1101 (DR11). Comparison of amino acid sequences of HCMV isolates revealed that the gB and gH epitope sequences recognized by human CD4+ T cells were not only conserved in clinical isolates from HCMV but also in CMV isolates from higher primates (chimpanzee, rhesus and baboon). Interestingly, these epitope sequences from chimpanzee, rhesus and baboon CMV are efficiently recognized by human CD4+ CTL. More importantly, we show that gB-specific T cells from humans can also efficiently lyse peptide-sensitized Patr-DR7+ cells from chimpanzees. These findings suggest that conserved gB and gH epitopes should be considered while designing a prophylactic vaccine against HCMV. In addition, they also provide a functional basis for the conservation of MHC class II lineages between humans and Old World prima...Continue Reading

References

Jan 1, 1992·European Journal of Immunology·S R BurrowsD J Moss
Nov 1, 1991·Reviews of Infectious Diseases·S R RiddellP D Greenberg
Aug 15, 1991·Analytical Biochemistry·R M ValerioN J Maeji
Sep 1, 1995·The Journal of Experimental Medicine·S FleuryR P Sékaly
Jun 1, 1996·Journal of Medical Virology·J I HopkinsL K Borysiewicz
Jan 1, 1996·Intervirology·W J Britt, M Mach
Sep 9, 1999·The Journal of Infectious Diseases·R F PassR L Burke
Jul 19, 2000·Current Opinion in Immunology·M J Reddehase
Jul 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A D BitmansourL J Picker
Nov 10, 2001·Hematology·John A. ZaiaJ. Sun
Mar 22, 2002·Journal of Virology·Martina SesterHans Köhler
Jul 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Arlene D BitmansourLouis J Picker
Jan 21, 2003·The Journal of General Virology·Andrew J DavisonGary S Hayward
Jun 5, 2003·Pharmacology & Therapeutics·Santo LandolfoDavid Lembo
Jun 18, 2003·The Journal of Experimental Medicine·Naglaa H ShoukryChristopher M Walker
Dec 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Naglaa H ShoukryChristopher M Walker

❮ Previous
Next ❯

Citations

Feb 28, 2008·Medical Microbiology and Immunology·Edward C P WallerMark R Wills
Feb 9, 2011·Immunology and Cell Biology·Scott R BurrowsRajiv Khanna
Feb 9, 2011·Immunology and Cell Biology·John J MilesDavid A Price
Jul 25, 2012·Proceedings of the National Academy of Sciences of the United States of America·Gavin M MasonJohn H Sinclair
Oct 12, 2005·The Journal of Experimental Medicine·Nagendra R HegdeDavid C Johnson
Jul 4, 2012·The Journal of Experimental Medicine·Yan ZhouChristopher M Walker
Mar 8, 2008·ILAR Journal·Lynn M Wachtman, Keith G Mansfield
Jan 13, 2009·Clinical Microbiology Reviews·Tania Crough, Rajiv Khanna
Nov 23, 2010·Expert Review of Vaccines·Heungsup Sung, Mark R Schleiss
Jul 25, 2009·Expert Review of Vaccines·Wolfgang Herr, Bodo Plachter
Nov 9, 2010·Virus Research·Sarah E JacksonMark R Wills
Jun 10, 2008·Immunology Letters·Cristina UlivieriGiovanna Del Pozzo
Apr 29, 2008·Current Opinion in Immunology·Pablo J van de BergRene van Lier
Jul 28, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M A BrehmR M Welsh
Feb 13, 2014·Immunological Reviews·Damian L TurnerDonna L Farber
Mar 19, 2014·Transplant International : Official Journal of the European Society for Organ Transplantation·Marc LúciaOriol Bestard
Nov 30, 2004·The Lancet Infectious Diseases·Maher K Gandhi, Rajiv Khanna
Apr 18, 2006·Nihon rinsho. Japanese journal of clinical medicine·Naoki Nozawa, Naoki Inoue
Dec 13, 2005·Trends in Molecular Medicine·Rajiv Khanna, Don J Diamond
Nov 20, 2013·Seminars in Immunology·Hilde Cheroutre, Mohammad Mushtaq Husain
Jun 6, 2007·Expert Review of Anti-infective Therapy·Jie Zhong, Rajiv Khanna
Oct 4, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chike O AbanaSimon A Mallal
Dec 22, 2017·Journal of Virology·Angela FueryPaul D Ling
Oct 23, 2015·Journal of Virology·Shilpi VermaChris A Benedict
Jul 20, 2005·Expert Review of Vaccines·Mark R Schleiss, Thomas C Heineman
Jul 20, 2007·Journal of the American Society of Nephrology : JASN·Liisa K Selin, Michael A Brehm
Jul 20, 2010·International Reviews of Immunology·Debora MartorelliRiccardo Dolcetti
Jun 12, 2013·Expert Review of Vaccines·Vijayendra DasariRajiv Khanna
Dec 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·David A PriceLouis J Picker
Oct 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Min KimAnthony L Cunningham
Sep 13, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Annette PachnioPaul A H Moss

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.