Cross-reactivity among p-amino group compounds in sulfonamide fixed drug eruption: diagnostic value of patch testing

Contact Dermatitis
P TorneroT Herrero

Abstract

We studied 28 patients with fixed drug eruption (FDE) caused by sulfonamide antibiotics to investigate cross-reactivity between sulfonamide derivatives and p-amino compounds and to explore the usefulness of patch testing, as an alternative to controlled oral challenge testing (COCT), in diagnosis within this clinical area. COCT with sulfamethoxazole (SMX), sulfadiazine (SDZ), sulfamethizole (SMZ), furosemide (FU), procaine (PRO) and glipizide (GPZ) was performed. Patch testing (PT) with SMX and SDZ was carried out. In all patients, the diagnosis of FDE was confirmed by positive COCT and allergy to trimethoprim ruled out by COCT. 42.8 and 31.8% of the SMX-induced FDE patients reacted to SMZ and SDZ, respectively. All patients (n = 28) tolerated FU, PRO and GPZ. COCT performed with the 3 sulfonamide antibiotics in 12 patients was positive in 2 subjects with the 3 drugs, in 2 patients only with SMX and SMZ and in the remaining 8, SMX was the only causative drug. PT was positive in 5 of 25 patients positive on COCT. The probability of obtaining a positive PT was higher among patients who had a residual lesion than that among those who lacked this. Cross-reactivity between different sulfonamide antibiotics is thus variable, being mo...Continue Reading

References

Feb 1, 1979·The British Journal of Dermatology·J S Pasricha
Nov 1, 1991·The Journal of Allergy and Clinical Immunology·Rebecca S Gruchalla, T J Sullivan
Jan 1, 1990·Dermatologica·M PicardoB Santucci
Apr 1, 1987·The British Journal of Dermatology·K AlankoS Reitamo
Jan 1, 1988·Dermatologica·A J KanwarM S Belhaj
May 1, 1985·The British Journal of Dermatology·K Kauppinen, S Stubb
Oct 1, 1987·The Journal of Allergy and Clinical Immunology·J R HansbroughD D Chaplin
Nov 1, 1970·The British Journal of Dermatology·J A Savin
Mar 1, 1982·Reviews of Infectious Diseases·H Jick
Dec 1, 1994·The Journal of Allergy and Clinical Immunology·C V MeekinsRebecca S Gruchalla
Dec 29, 1998·International Journal of Dermatology·A Mahboob, T S Haroon
Jan 25, 2000·Clinical Therapeutics·R PattersonJ Lefkowith
May 2, 2001·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·S KnowlesN H Shear
May 31, 2001·American Journal of Contact Dermatitis : Official Journal of the American Contact Dermatitis Society·R L RietschelD V Belsito
Oct 31, 2001·Contact Dermatitis·J F SilvestreR Botella
Nov 13, 2001·The British Journal of Dermatology·J A Savin
Dec 1, 1961·Archives of Dermatology·A L WELSH, M EDE
Jul 3, 1964·Deutsche medizinische Wochenschrift·G GOERZH G MEIERS

Citations

Mar 7, 2008·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Donald A Dibbern, Anthony Montanaro
Jun 4, 2008·AIDS·N H ShearElizabeth J Phillips
Jun 4, 2005·Contact Dermatitis·A Yokoyama, H Hara
Apr 7, 2010·Drug Design, Development and Therapy·Chaouki K Khoury, James R Couch
Mar 1, 2011·Annales Françaises D'anesthèsie Et De Rèanimation·François LavaudC Ponvert
Sep 14, 2013·Dermatitis : Contact, Atopic, Occupational, Drug·Marcella Rita AquinoLuz Fonacier
Jul 16, 2014·Immunology and Allergy Clinics of North America·Antonino Romano, Richard Warrington
Feb 26, 2014·The Journal of Allergy and Clinical Immunology. in Practice·Antonino Romano, Jean-Christoph Caubet
Mar 21, 2007·Journal of Pharmaceutical and Biomedical Analysis·Céline CouteauLaurence J M Coiffard
Jun 10, 2004·Contact Dermatitis·A PrietoT Herrero
Nov 23, 2013·International Journal of Dermatology·Marisol Contreras-SteylsEnrique Herrera-Ceballos
Jun 9, 2016·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Nina Therese Hagen, Olav Spigset
Jul 10, 2004·Immunology and Allergy Clinics of North America·Christopher G Slatore, Stephen A Tilles
Aug 15, 2013·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Nicole R Wulf, Karl A Matuszewski
Jun 8, 2018·Current Allergy and Asthma Reports·Joshua M DornGerald W Volcheck
Sep 15, 2019·The Journal of Allergy and Clinical Immunology. in Practice·Patrick GleesonOlajumoke Fadugba

Related Concepts

Topical anesthetic
Microbicides
Cross Reactions
Morbilliform Drug Reaction
Glupitel
Hypoglycemic Effect
Patch Tests
Procaina Serra
Sulfonamides

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