PMID: 15238366Jul 9, 2004Paper

Cross-reactivity and tolerability of cephalosporins in patients with immediate hypersensitivity to penicillins

Annals of Internal Medicine
Antonino RomanoJean-Louis Guéant

Abstract

In patients with documented IgE-mediated hypersensitivity to penicillins, data on sensitization to cephalosporins vary. Administering cephalosporins to such patients is often deferred because of the risk for cross-reactivity. To assess the cross-reactivity with cephalosporins and its potential determinants in patients with documented penicillin allergy. Prospective study in patients without clinical indications for cephalosporin treatment. Italy. 128 consecutive patients who sustained anaphylactic shock (n = 81) or urticaria (n = 47) and had positive results on skin tests for at least 1 of the penicillin reagents tested. All patients were skin tested with cephalothin, cefamandole, cefuroxime, ceftazidime, ceftriaxone, and cefotaxime. Patients with negative results for the last 4 cephalosporins were challenged with cefuroxime axetil and ceftriaxone. 14 patients (10.9% [95% CI, 6.1% to 17.7%]) had positive results on skin tests for cephalosporins, mostly for cephalothin or cefamandole. Skin test results for the minor determinant mixture were positive in 10 of 14 patients (71.4%) with cross-reactivity and 44 of 114 patients (38.6%) without cross-reactivity (odds ratio, 3.90 [CI, 1.17 to 13.40]; P = 0.0189). All 101 patients with n...Continue Reading

Citations

Jan 22, 2005·Current Allergy and Asthma Reports·Pascal Demoly, Antonino Romano
Nov 8, 2007·Current Allergy and Asthma Reports·Brett L Buchmiller, David A Khan
Apr 3, 2013·Clinical Reviews in Allergy & Immunology·Scott D Dickson, Kimberly C Salazar
Jul 2, 2005·The Journal of Allergy and Clinical Immunology·Patrick H WinIftikhar Hussain
Oct 4, 2007·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Javed Sheikh
Dec 15, 2006·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Miguel ParkJames T C Li
Jun 30, 2006·The New England Journal of Medicine·Antonino RomanoJean-Louis Guéant
Sep 27, 2006·Pharmacogenetics and Genomics·Rosa-Maria Guéant-RodriguezJean-Louis Guéant
Jan 16, 2014·Anesthesia Progress·Daniel E Becker
Mar 1, 2011·Annales Françaises D'anesthèsie Et De Rèanimation·F LavaudC Ponvert
Nov 8, 2008·Médecine et maladies infectieuses·A ChaabaneM Chakroun
Jul 16, 2014·Immunology and Allergy Clinics of North America·Antonino Romano, Richard Warrington
Feb 26, 2014·The Journal of Allergy and Clinical Immunology. in Practice·Antonino Romano, Jean-Christoph Caubet
May 9, 2008·Expert Opinion on Drug Safety·Esther MorenoFélix Lorente
Feb 18, 2014·The Journal of Thoracic and Cardiovascular Surgery·David J CookJoseph A Dearani
Aug 31, 2013·Journal of Cataract and Refractive Surgery·Anders BehndigMarie-José Tassignon
Jul 26, 2008·Journal of the American Pharmacists Association : JAPhA·Daryl D DePestelJames A Hadley
Feb 24, 2016·Current Allergy and Asthma Reports·Antonino RomanoRocco Luigi Valluzzi
Jul 3, 2013·The Medical Clinics of North America·Jenny Wright, Douglas S Paauw
Feb 26, 2014·The Journal of Allergy and Clinical Immunology. in Practice·Matthieu PicardLouis Paradis
Jan 29, 2013·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Leon KaoDavid A Khan
Nov 28, 2012·Allergologia et immunopathologia·J S YusinM Baum
Jan 1, 2009·Medical Journal, Armed Forces India·G D Choudhury, Vikas Agarwal
Jul 12, 2011·The Journal of Emergency Medicine·James D CampagnaBryan D Hayes
Oct 5, 2010·The Journal of Allergy and Clinical Immunology·Antonino RomanoPhilippe Jean Bousquet
Oct 12, 2010·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·UNKNOWN Joint Task Force on Practice ParametersUNKNOWN Joint Council of Allergy, Asthma and Immunology
Mar 5, 2010·The Journal of Allergy and Clinical Immunology·David A Khan, Roland Solensky
Apr 17, 2009·The Journal of Allergy and Clinical Immunology·Marina Atanasković-MarkovićAntonino Romano
Dec 22, 2015·The Journal of Allergy and Clinical Immunology·Meghan N JeffresGarrett E Schramm
Jun 15, 2007·Lancet·Stefan Wöhrl, Alexandra Geusau
Mar 14, 2007·Diagnostic Microbiology and Infectious Disease·Michael E Pichichero
Nov 7, 2006·Immunology and Allergy Clinics of North America·Paul A Greenberger
Jan 6, 2009·The British Journal of Dermatology·J WatonA Barbaud
May 4, 2011·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·C PonvertJ De Blic
May 18, 2012·Dermatologic Therapy·Lucia Diaz, Ana M Ciurea
Aug 5, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M J TorresM Blanca
Jan 28, 2015·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R MirakianUNKNOWN Standards of Care Committee of the British Society for Allergy and Clinical Immunology
Mar 16, 2005·Toxicology·Antonino RomanoJean-Louis Guéant
Mar 28, 2016·The Journal of Allergy and Clinical Immunology·Antonino RomanoDonato Quaratino
Jul 1, 2008·The American Journal of Medicine·Anne B Yates

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

© 2022 Meta ULC. All rights reserved