PMID: 7517148Mar 1, 1994Paper

Cross-reactivity between autoimmune anti-U1 snRNP antibodies and neutralizing epitopes of HIV-1 gp120/41

AIDS Research and Human Retroviruses
A Douvas, Y Takehana

Abstract

We report extensive amino acid sequence homology between HIV-1 gp120/41, and > 33% of a U1 RNA-associated splicing protein, 70K. The latter is a target of autoimmune anti-RNP antibodies in mixed connective tissue disease (MCTD). The homologies, involving dominant epitopes of 70K and neutralizing epitopes of gp120/41, are the basis for mutual antibody cross-reactivity. A key finding is that the epitope GRAFVTIG in the V3 loop of gp120 (strain IIIB) is homologous to the functionally essential U1 RNA-binding site of 70K. ELISA data reveal a mean reactivity of anti-RNP antibodies to V3 IIIB that is as high as that of HIV sera. V3 MN, containing the framework sequence G-AF-T, also cross-reacts with anti-RNP antibodies, as do hydrophilic epitopes in gp41 homologous to the COOH end of 70K. Further, there is strong cross-reactivity between HIV sera and 70K in Western blots. In contrast, antibodies from a related autoimmune disorder, Sjögren's syndrome (SS), are neither V3 nor gp41 selective. We conclude that the substantial cross-reactivities reported here are due to conserved, antigenically dominant B cell epitopes having homologous counterparts in 70K and gp120/41. Because antibody production in both MCTD and HIV-1 infection is T cel...Continue Reading

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Citations

Jan 24, 2004·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Janusz Prokop, Pawel P Jagodzinski
Apr 10, 1996·AIDS Research and Human Retroviruses·M FrazianoV Colizzi
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Apr 7, 2010·The Journal of Experimental Medicine·M Anthony MoodyBarton F Haynes
Jul 20, 2002·Journal of Autoimmunity·Michel SoulardChristian-Jacques Larsen
Jun 11, 2014·Seminars in Arthritis and Rheumatism·Girish M ModyThozama Dubula
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Nov 1, 1995·British Journal of Haematology·A G Dalgleish

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